Neurogenic muscle hypertrophy - Report of two cases

D. Pareyson; L. Morandi; V. Scaioli; R. Marazzi; A. Boiardi; A. Sghirlanzoni

doi:10.1007/BF00314459

Neurogenic muscle hypertrophy - Report of two cases

D. Pareyson, L. Morandi, V. Scaioli, R. Marazzi, A. Boiardi, A. Sghirlanzoni

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Muscle hypertrophy is rare in denervating diseases. A patient with calf enlargement associated with L5-S1 radiculopathy and another with thenar, hypothenar, forearm and calf muscle hypertrophy in the course of chronic relapsing inflammatory demyelinating polyneuropathy are described. Gastrocnemius muscle biopsy revealed both type I and type II fibre hypertrophy in the former case and predominant type I fibre hypertrophy in the latter. Passive stretching and abnormal spontaneous muscular activity might have played a role in the origin of hypertrophy in both patients, but a satisfactory explanation for denervation hypertrophy has yet to be provided.

Original language	English
Pages (from-to)	292-295
Number of pages	4
Journal	Journal of Neurology
Volume	236
Issue number	5
DOIs	https://doi.org/10.1007/BF00314459
Publication status	Published - Jul 1989

Keywords

Muscle hypertrophy
Neuropathies
Spontaneous muscular activity
Stretching

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1007/BF00314459

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abstract = "Muscle hypertrophy is rare in denervating diseases. A patient with calf enlargement associated with L5-S1 radiculopathy and another with thenar, hypothenar, forearm and calf muscle hypertrophy in the course of chronic relapsing inflammatory demyelinating polyneuropathy are described. Gastrocnemius muscle biopsy revealed both type I and type II fibre hypertrophy in the former case and predominant type I fibre hypertrophy in the latter. Passive stretching and abnormal spontaneous muscular activity might have played a role in the origin of hypertrophy in both patients, but a satisfactory explanation for denervation hypertrophy has yet to be provided.",

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T1 - Neurogenic muscle hypertrophy - Report of two cases

AU - Pareyson, D.

AU - Morandi, L.

AU - Scaioli, V.

AU - Marazzi, R.

AU - Boiardi, A.

AU - Sghirlanzoni, A.

PY - 1989/7

Y1 - 1989/7

N2 - Muscle hypertrophy is rare in denervating diseases. A patient with calf enlargement associated with L5-S1 radiculopathy and another with thenar, hypothenar, forearm and calf muscle hypertrophy in the course of chronic relapsing inflammatory demyelinating polyneuropathy are described. Gastrocnemius muscle biopsy revealed both type I and type II fibre hypertrophy in the former case and predominant type I fibre hypertrophy in the latter. Passive stretching and abnormal spontaneous muscular activity might have played a role in the origin of hypertrophy in both patients, but a satisfactory explanation for denervation hypertrophy has yet to be provided.

AB - Muscle hypertrophy is rare in denervating diseases. A patient with calf enlargement associated with L5-S1 radiculopathy and another with thenar, hypothenar, forearm and calf muscle hypertrophy in the course of chronic relapsing inflammatory demyelinating polyneuropathy are described. Gastrocnemius muscle biopsy revealed both type I and type II fibre hypertrophy in the former case and predominant type I fibre hypertrophy in the latter. Passive stretching and abnormal spontaneous muscular activity might have played a role in the origin of hypertrophy in both patients, but a satisfactory explanation for denervation hypertrophy has yet to be provided.

KW - Muscle hypertrophy

KW - Neuropathies

KW - Spontaneous muscular activity

KW - Stretching

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Neurogenic muscle hypertrophy - Report of two cases

Abstract

Keywords

ASJC Scopus subject areas

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