Neurogenic muscle hypertrophy - Report of two cases

D. Pareyson, L. Morandi, V. Scaioli, R. Marazzi, A. Boiardi, A. Sghirlanzoni

Research output: Contribution to journalArticlepeer-review


Muscle hypertrophy is rare in denervating diseases. A patient with calf enlargement associated with L5-S1 radiculopathy and another with thenar, hypothenar, forearm and calf muscle hypertrophy in the course of chronic relapsing inflammatory demyelinating polyneuropathy are described. Gastrocnemius muscle biopsy revealed both type I and type II fibre hypertrophy in the former case and predominant type I fibre hypertrophy in the latter. Passive stretching and abnormal spontaneous muscular activity might have played a role in the origin of hypertrophy in both patients, but a satisfactory explanation for denervation hypertrophy has yet to be provided.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalJournal of Neurology
Issue number5
Publication statusPublished - Jul 1989


  • Muscle hypertrophy
  • Neuropathies
  • Spontaneous muscular activity
  • Stretching

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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