Neurohormonal activation and inflammation in chronic cardiopulmonary disease: A brief systematic review

Wolfram Doehner, Stephan Von Haehling, Stefan D. Anker, Mitja Lainscak

Research output: Contribution to journalArticle

Abstract

Chronic cardiopulmonary disease typically induces and maintains (over)activation of several phylogenetically old adaptational and defensive mechanisms. Activation was usually needed for a limited period during acute danger or injury. In chronic disease conditions, however, those mechanisms are kept activated for longer periods. Eventually, irreversible damage is done and this contributes to impaired function and worse prognosis in a variety of chronic disease. Landmark trials in chronic heart failure have provided robust evidence for prognostic benefit for neurohormonal antagonists. Retrospective and epidemiological data for their beneficial effect in chronic obstructive pulmonary disease begin to accumulate and new fields (e.g. cancer and stroke) could be pending in the future.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalWiener Klinische Wochenschrift
Volume121
Issue number9-10
DOIs
Publication statusPublished - 2009

Keywords

  • Cachexia
  • Cancer
  • Chronic heart failure
  • Chronic obstructive pulmonary disease
  • Inflammation
  • Neurohormones
  • Renin-angiotensin-aldosterone
  • Stroke
  • Sympatethic system

ASJC Scopus subject areas

  • Medicine(all)

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