Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease

Aidan P. Bolger, Rakesh Sharma, Wei Li, Marjolein Leenarts, Paul R. Kalra, Michael Kemp, Andrew J S Coats, Stefan D. Anker, Michael A. Gatzoulis

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Neurohormonal activation characterizes chronic heart failure, relates to outcome, and is a therapeutic target. It is not known whether a similar pattern of neurohormonal activation exists in adults with congenital heart disease and, if so, whether it relates to common measures of disease severity or whether cardiac anatomy is a better discriminant. Methods and Results - Concentrations of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1), renin, aldosterone, norepinephrine, and epinephrine were determined in 53 adults with congenital heart disease, comprising 4 distinct anatomic subgroups (29 female; 33.5 ± 1.5 years of age; New York Heart Association class 2.0 ± 0.1, mean ± SEM) and 15 healthy control subjects (8 female; 32.3 ± 1.3 years of age). Systemic ventricular function was graded by a blinded echocardiographer as normal or mildly, moderately, or severely impaired. Adults with congenital heart disease had elevated levels of ANP (56.6 versus 3.1 pmol/L), BNP (35.8 versus 5.7 pmol/L), ET-1 (2.5 versus 0.7 pmol/L, all P

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalCirculation
Volume106
Issue number1
DOIs
Publication statusPublished - Jul 1 2002

Keywords

  • Heart defects, congenital
  • Heart diseases
  • Heart failure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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