Abstract
Objective: The objective of this study is to determine the main neuroimaging findings of microcephalic newborns with possible Zika virus (ZIKV) intrauterine infection using transfontanellar cranial ultrasound. Methods: We performed a retrospective study to describe the main neuroimaging findings in newborns with microcephaly and possible association with congenital ZIKV infection. Microcephaly was defined in the postnatal period using transfontanellar cranial examination which was performed using both two- (2D) and three-dimensional (3D) ultrasound. Results: One hundred and fifty newborns with microcephaly were identified during the study period. The mean ± (standard deviation - SD) of cephalic perimeter was 28.5 ± 4.2 cm (range, 25–38 cm). Transfontanellar neuroimaging patterns detected cerebral calcifications, neuronal migrational abnormalities, dysgenesis of the corpus callosum, and cerebellar atrophy in 34.9%, 31.1%, 26%, and 16.2%, respectively. Hydrocephalus was seen in 28% of overall newborns. A history of maculopapular rash was present in almost half of the mothers (46.1%). Conclusion: Neuroimaging patterns by means of transfontanellar ultrasound are accurate and diagnostic investigations of brain pathology in newborns affected by microcephaly and possible intrauterine ZIKV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 493-501 |
| Number of pages | 9 |
| Journal | Journal of Maternal-Fetal and Neonatal Medicine |
| Volume | 32 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 1 2019 |
| Externally published | Yes |
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Keywords
- Congenital Zika virus infection
- microcephaly
- newborns
- transfontanelle cranial ultrasound
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynaecology
Cite this
Neuroimaging findings using transfontanellar ultrasound in newborns with microcephaly : a possible association with congenital Zika virus infection. / Ximenes, Ana Sofia França Cruz; Pires, Pedro; Werner, Heron; Jungmann, Patricia Mello; Rolim Filho, Epitácio Leite; Andrade, Etiene Pedrosa; Lemos, Roberto Souza; Peixoto, Alberto Borges; Zare Mehrjardi, Mohammad; Tonni, Gabriele; Araujo Júnior, Edward.
In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 32, No. 3, 01.02.2019, p. 493-501.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroimaging findings using transfontanellar ultrasound in newborns with microcephaly
T2 - a possible association with congenital Zika virus infection
AU - Ximenes, Ana Sofia França Cruz
AU - Pires, Pedro
AU - Werner, Heron
AU - Jungmann, Patricia Mello
AU - Rolim Filho, Epitácio Leite
AU - Andrade, Etiene Pedrosa
AU - Lemos, Roberto Souza
AU - Peixoto, Alberto Borges
AU - Zare Mehrjardi, Mohammad
AU - Tonni, Gabriele
AU - Araujo Júnior, Edward
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Objective: The objective of this study is to determine the main neuroimaging findings of microcephalic newborns with possible Zika virus (ZIKV) intrauterine infection using transfontanellar cranial ultrasound. Methods: We performed a retrospective study to describe the main neuroimaging findings in newborns with microcephaly and possible association with congenital ZIKV infection. Microcephaly was defined in the postnatal period using transfontanellar cranial examination which was performed using both two- (2D) and three-dimensional (3D) ultrasound. Results: One hundred and fifty newborns with microcephaly were identified during the study period. The mean ± (standard deviation - SD) of cephalic perimeter was 28.5 ± 4.2 cm (range, 25–38 cm). Transfontanellar neuroimaging patterns detected cerebral calcifications, neuronal migrational abnormalities, dysgenesis of the corpus callosum, and cerebellar atrophy in 34.9%, 31.1%, 26%, and 16.2%, respectively. Hydrocephalus was seen in 28% of overall newborns. A history of maculopapular rash was present in almost half of the mothers (46.1%). Conclusion: Neuroimaging patterns by means of transfontanellar ultrasound are accurate and diagnostic investigations of brain pathology in newborns affected by microcephaly and possible intrauterine ZIKV infection.
AB - Objective: The objective of this study is to determine the main neuroimaging findings of microcephalic newborns with possible Zika virus (ZIKV) intrauterine infection using transfontanellar cranial ultrasound. Methods: We performed a retrospective study to describe the main neuroimaging findings in newborns with microcephaly and possible association with congenital ZIKV infection. Microcephaly was defined in the postnatal period using transfontanellar cranial examination which was performed using both two- (2D) and three-dimensional (3D) ultrasound. Results: One hundred and fifty newborns with microcephaly were identified during the study period. The mean ± (standard deviation - SD) of cephalic perimeter was 28.5 ± 4.2 cm (range, 25–38 cm). Transfontanellar neuroimaging patterns detected cerebral calcifications, neuronal migrational abnormalities, dysgenesis of the corpus callosum, and cerebellar atrophy in 34.9%, 31.1%, 26%, and 16.2%, respectively. Hydrocephalus was seen in 28% of overall newborns. A history of maculopapular rash was present in almost half of the mothers (46.1%). Conclusion: Neuroimaging patterns by means of transfontanellar ultrasound are accurate and diagnostic investigations of brain pathology in newborns affected by microcephaly and possible intrauterine ZIKV infection.
KW - Congenital Zika virus infection
KW - microcephaly
KW - newborns
KW - transfontanelle cranial ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85031405195&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031405195&partnerID=8YFLogxK
U2 - 10.1080/14767058.2017.1384459
DO - 10.1080/14767058.2017.1384459
M3 - Article
VL - 32
SP - 493
EP - 501
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - 3
ER -