Neuroimaging in amyotrophic lateral sclerosis

Martin R. Turner, Federica Agosta, Peter Bede, Varan Govind, Dorothée Lulé, Esther Verstraete

Research output: Contribution to journalArticlepeer-review


The catastrophic system failure in amyotrophic lateral sclerosis is characterized by progressive neurodegeneration within the corticospinal tracts, brainstem nuclei and spinal cord anterior horns, with an extra-motor pathology that has overlap with frontotemporal dementia. The development of computed tomography and, even more so, MRI has brought insights into neurological disease, previously only available through post-mortem study. Although largely research-based, radionuclide imaging has continued to provide mechanistic insights into neurodegenerative disorders. The evolution of MRI to use advanced sequences highly sensitive to cortical and white matter structure, parenchymal metabolites and blood flow, many of which are now applicable to the spinal cord as well as the brain, make it a uniquely valuable tool for the study of a multisystem disorder such as amyotrophic lateral sclerosis. This comprehensive review considers the full range of neuroimaging techniques applied to amyotrophic lateral sclerosis over the last 25 years, the biomarkers they have revealed and future developments.

Original languageEnglish
Pages (from-to)319-337
Number of pages19
JournalBiomarkers in Medicine
Issue number3
Publication statusPublished - Jun 2012


  • diffusion tensor imaging
  • functional imaging
  • magnetic resonance spectroscopy
  • morphometry
  • motor neuron disease
  • MRI
  • PET
  • resting state

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery


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