Abstract
Neuroimaging studies are of crucial relevance in defining the pathophysiology of restless legs syndrome (RLS). MRI studies showed no structural brain lesions and confirmed a central iron deficiency. Structural and functional studies showed an involvement of the thalamus, sensorimotor cortical areas, and cerebellum in RLS and assessed neurotransmission abnormalities in the dopaminergic and opiate systems. Finally, glutamatergic hyperactivity has been proposed as a cause of disrupted and shortened sleep in RLS. Differences among the results of the studies make it difficult to draw any definitive conclusions, thus, suggesting the need for future research.
| Original language | English |
|---|---|
| Pages (from-to) | 215-226 |
| Number of pages | 12 |
| Journal | Sleep Medicine Clinics |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1 2015 |
Fingerprint
Keywords
- Diffusion tensor imaging
- MRI
- Neuroimaging
- PET
- Restless legs syndrome
- Single-photon emission computed tomography
- Voxel-based morphometry
- Willis-Ekbom disease
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuropsychology and Physiological Psychology
- Clinical Psychology
- Clinical Neurology
Cite this
Neuroimaging in Restless Legs Syndrome. / Provini, Federica; Chiaro, Giacomo.
In: Sleep Medicine Clinics, Vol. 10, No. 3, 01.09.2015, p. 215-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroimaging in Restless Legs Syndrome
AU - Provini, Federica
AU - Chiaro, Giacomo
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Neuroimaging studies are of crucial relevance in defining the pathophysiology of restless legs syndrome (RLS). MRI studies showed no structural brain lesions and confirmed a central iron deficiency. Structural and functional studies showed an involvement of the thalamus, sensorimotor cortical areas, and cerebellum in RLS and assessed neurotransmission abnormalities in the dopaminergic and opiate systems. Finally, glutamatergic hyperactivity has been proposed as a cause of disrupted and shortened sleep in RLS. Differences among the results of the studies make it difficult to draw any definitive conclusions, thus, suggesting the need for future research.
AB - Neuroimaging studies are of crucial relevance in defining the pathophysiology of restless legs syndrome (RLS). MRI studies showed no structural brain lesions and confirmed a central iron deficiency. Structural and functional studies showed an involvement of the thalamus, sensorimotor cortical areas, and cerebellum in RLS and assessed neurotransmission abnormalities in the dopaminergic and opiate systems. Finally, glutamatergic hyperactivity has been proposed as a cause of disrupted and shortened sleep in RLS. Differences among the results of the studies make it difficult to draw any definitive conclusions, thus, suggesting the need for future research.
KW - Diffusion tensor imaging
KW - MRI
KW - Neuroimaging
KW - PET
KW - Restless legs syndrome
KW - Single-photon emission computed tomography
KW - Voxel-based morphometry
KW - Willis-Ekbom disease
UR - http://www.scopus.com/inward/record.url?scp=84940459524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940459524&partnerID=8YFLogxK
U2 - 10.1016/j.jsmc.2015.05.006
DO - 10.1016/j.jsmc.2015.05.006
M3 - Article
VL - 10
SP - 215
EP - 226
JO - Sleep Medicine Clinics
JF - Sleep Medicine Clinics
SN - 1556-407X
IS - 3
ER -