Neuroimaging of malformation of cortical development

Dora Zlatareva, I. Tournev, A. Rossi, V. Hadjidekov

Research output: Contribution to journalArticlepeer-review


Malformations of cortical development (MCD) are heterogeneous group of disease which result from disruption of 3 main stages of cortical development. The common clinical presentation is refractory epilepsy and or developmental delay. The aim of this paper is to describe and analyze magnetic resonance (MR) findings and to present protocol for examination. We analyze MR findings in 17 patients with MCD. The average age was 12, 1 year (from 2 months - 57 years). The main indications from reference physician are epilepsy and developmental delay. In 12 patients 1.5T MR was performed, and in 5-0.5T. Subependymal heterotopias was found in 6 patients, focal cortical dysplasia - 3, polymicrogyria - 3, schizencephaly - 2, hemimegalencephaly - 1, lizencephaly - 1, tuberous sclerosis - 1. The most common MCD are heterotopias, focal cortical dysplasia, polymicrogyria, schizencephaly, pachygyria and lizencephaly. In our study the number of patients is not big enough to make a conclusion about frequency of the forms of MCD and our goal is to analyze MR findings which are not well studied in our country. MRI is the method of choice for diagnosis of MCD. The protocol should be different from routine brain protocol to interpret the images with good quality and not miss the pathology. Knowledge of MR findings in MCD would help for genetic counseling in some cases or can predict prognosis in some patients.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalRentgenologiya i Radiologiya
Issue number1
Publication statusPublished - 2012


  • CNS
  • Epilepsy
  • Malformation of cortical development
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Neuroimaging of malformation of cortical development'. Together they form a unique fingerprint.

Cite this