TY - JOUR
T1 - Neuroimmune interactions in patients with inflammatory bowel diseases
T2 - Disease activity and clinical behavior based on Substance P serum levels
AU - Tavano, Francesca
AU - di Mola, F. Francesco
AU - Latiano, Anna
AU - Palmieri, Orazio
AU - Bossa, Fabrizio
AU - Valvano, Maria Rosa
AU - Latiano, Tiziana
AU - Annese, Vito
AU - Andriulli, Angelo
AU - di Sebastiano, Pierluigi
PY - 2012/6
Y1 - 2012/6
N2 - Background and aim: The neuropeptide Substance P, plays a key role in modulating neuroimmune interactions in patients with inflammatory bowel diseases. We analyzed Substance P serum levels in patients with ulcerative colitis and Crohn's disease, to detail the involvement of the neuropeptide in the pathophysiology of these disorders. Methods: Serum samples were collected from 61 patients with ulcerative colitis (24 with active and 37 with inactive disease), 66 patients with Crohn's disease (29 with active and 37 with inactive disease) and 45 healthy subjects, enrolled into the study. Neuropetide serum levels were measured by means of an ELISA/EIA. Associations with disease activity and patients clinical features were also taken into account. Results: Compared to controls, Substance P serum levels were significantly increased in both patients with ulcerative colitis and Crohn's disease, (p
AB - Background and aim: The neuropeptide Substance P, plays a key role in modulating neuroimmune interactions in patients with inflammatory bowel diseases. We analyzed Substance P serum levels in patients with ulcerative colitis and Crohn's disease, to detail the involvement of the neuropeptide in the pathophysiology of these disorders. Methods: Serum samples were collected from 61 patients with ulcerative colitis (24 with active and 37 with inactive disease), 66 patients with Crohn's disease (29 with active and 37 with inactive disease) and 45 healthy subjects, enrolled into the study. Neuropetide serum levels were measured by means of an ELISA/EIA. Associations with disease activity and patients clinical features were also taken into account. Results: Compared to controls, Substance P serum levels were significantly increased in both patients with ulcerative colitis and Crohn's disease, (p
KW - Disease activity
KW - Disease behavior
KW - Inflammatory bowel disease
KW - Neuroimmune inflammation
KW - Substance P
UR - http://www.scopus.com/inward/record.url?scp=84860834782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860834782&partnerID=8YFLogxK
U2 - 10.1016/j.crohns.2011.11.004
DO - 10.1016/j.crohns.2011.11.004
M3 - Article
C2 - 22398048
AN - SCOPUS:84860834782
VL - 6
SP - 563
EP - 570
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
SN - 1873-9946
IS - 5
ER -