Neuroimmune interactions in patients with inflammatory bowel diseases: Disease activity and clinical behavior based on Substance P serum levels

Francesca Tavano; F. Francesco di Mola; Anna Latiano; Orazio Palmieri; Fabrizio Bossa; Maria Rosa Valvano; Tiziana Latiano; Vito Annese; Angelo Andriulli; Pierluigi di Sebastiano

doi:10.1016/j.crohns.2011.11.004

Neuroimmune interactions in patients with inflammatory bowel diseases: Disease activity and clinical behavior based on Substance P serum levels

Francesca Tavano, F. Francesco di Mola, Anna Latiano, Orazio Palmieri, Fabrizio Bossa, Maria Rosa Valvano, Tiziana Latiano, Vito Annese, Angelo Andriulli, Pierluigi di Sebastiano

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aim: The neuropeptide Substance P, plays a key role in modulating neuroimmune interactions in patients with inflammatory bowel diseases. We analyzed Substance P serum levels in patients with ulcerative colitis and Crohn's disease, to detail the involvement of the neuropeptide in the pathophysiology of these disorders. Methods: Serum samples were collected from 61 patients with ulcerative colitis (24 with active and 37 with inactive disease), 66 patients with Crohn's disease (29 with active and 37 with inactive disease) and 45 healthy subjects, enrolled into the study. Neuropetide serum levels were measured by means of an ELISA/EIA. Associations with disease activity and patients clinical features were also taken into account. Results: Compared to controls, Substance P serum levels were significantly increased in both patients with ulcerative colitis and Crohn's disease, (p

Original language	English
Pages (from-to)	563-570
Number of pages	8
Journal	Journal of Crohn's & colitis
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/j.crohns.2011.11.004
Publication status	Published - Jun 2012

Keywords

Disease activity
Disease behavior
Inflammatory bowel disease
Neuroimmune inflammation
Substance P

ASJC Scopus subject areas

Gastroenterology

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Tavano, F., di Mola, F. F., Latiano, A., Palmieri, O., Bossa, F., Valvano, M. R., Latiano, T., Annese, V., Andriulli, A., & di Sebastiano, P. (2012). Neuroimmune interactions in patients with inflammatory bowel diseases: Disease activity and clinical behavior based on Substance P serum levels. Journal of Crohn's & colitis, 6(5), 563-570. https://doi.org/10.1016/j.crohns.2011.11.004

Neuroimmune interactions in patients with inflammatory bowel diseases : Disease activity and clinical behavior based on Substance P serum levels. / Tavano, Francesca; di Mola, F. Francesco; Latiano, Anna ; Palmieri, Orazio ; Bossa, Fabrizio; Valvano, Maria Rosa; Latiano, Tiziana; Annese, Vito; Andriulli, Angelo; di Sebastiano, Pierluigi.

In: Journal of Crohn's & colitis, Vol. 6, No. 5, 06.2012, p. 563-570.

Research output: Contribution to journal › Article › peer-review

Tavano, F, di Mola, FF, Latiano, A , Palmieri, O , Bossa, F, Valvano, MR, Latiano, T, Annese, V, Andriulli, A & di Sebastiano, P 2012, 'Neuroimmune interactions in patients with inflammatory bowel diseases: Disease activity and clinical behavior based on Substance P serum levels', Journal of Crohn's & colitis, vol. 6, no. 5, pp. 563-570. https://doi.org/10.1016/j.crohns.2011.11.004

Tavano, Francesca ; di Mola, F. Francesco ; Latiano, Anna ; Palmieri, Orazio ; Bossa, Fabrizio ; Valvano, Maria Rosa ; Latiano, Tiziana ; Annese, Vito ; Andriulli, Angelo ; di Sebastiano, Pierluigi. / Neuroimmune interactions in patients with inflammatory bowel diseases : Disease activity and clinical behavior based on Substance P serum levels. In: Journal of Crohn's & colitis. 2012 ; Vol. 6, No. 5. pp. 563-570.

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AU - Valvano, Maria Rosa

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