Neuroimmune interactions in patients with inflammatory bowel diseases: Disease activity and clinical behavior based on Substance P serum levels

Francesca Tavano, F. Francesco di Mola, Anna Latiano, Orazio Palmieri, Fabrizio Bossa, Maria Rosa Valvano, Tiziana Latiano, Vito Annese, Angelo Andriulli, Pierluigi di Sebastiano

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aim: The neuropeptide Substance P, plays a key role in modulating neuroimmune interactions in patients with inflammatory bowel diseases. We analyzed Substance P serum levels in patients with ulcerative colitis and Crohn's disease, to detail the involvement of the neuropeptide in the pathophysiology of these disorders. Methods: Serum samples were collected from 61 patients with ulcerative colitis (24 with active and 37 with inactive disease), 66 patients with Crohn's disease (29 with active and 37 with inactive disease) and 45 healthy subjects, enrolled into the study. Neuropetide serum levels were measured by means of an ELISA/EIA. Associations with disease activity and patients clinical features were also taken into account. Results: Compared to controls, Substance P serum levels were significantly increased in both patients with ulcerative colitis and Crohn's disease, (p

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalJournal of Crohn's & colitis
Volume6
Issue number5
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Disease activity
  • Disease behavior
  • Inflammatory bowel disease
  • Neuroimmune inflammation
  • Substance P

ASJC Scopus subject areas

  • Gastroenterology

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