Neuroinflammation and the genetics of Alzheimer's disease: The search for a pro-inflammatory phenotype

C. Franceschi, S. Valensin, F. Lescai, F. Olivieri, F. Licastro, L. M E Grimaldi, D. Monti, G. De Benedictis, M. Bonafè

Research output: Contribution to journalArticlepeer-review

Abstract

The role of interleukin 1 (IL-1) and interleukin 6 (IL-6) in the pathogenesis of Alzheimer's disease (AD) is reviewed within the framework of "inflamm-aging", i.e., the characteristic chronic pro-inflammatory status which develops in old age, and neuroinflammation, i.e., the peculiar inflammatory process which is present in the brain of AD patients. In particular, the data suggesting that several IL-1 and IL-6 gene polymorphisms can contribute to the risk of developing AD are reviewed. The possibility as well as the difficulty in identifying a pro-inflammatory phenotype, and its importance for the prevention, diagnosis and therapy of AD and other age-related pathologies are discussed.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalAging clinical and experimental research
Volume13
Issue number3
Publication statusPublished - 2001

Keywords

  • Aging
  • Alzheimer's disease
  • Genetics of AD
  • Inflamm-aging
  • Neuroinflammation
  • Pro-inflammatory phenotype

ASJC Scopus subject areas

  • Ageing

Fingerprint

Dive into the research topics of 'Neuroinflammation and the genetics of Alzheimer's disease: The search for a pro-inflammatory phenotype'. Together they form a unique fingerprint.

Cite this