Neuroinflammation as a target for glaucoma therapy

Annagrazia Adornetto, Rossella Russo, Vincenzo Parisi

Research output: Contribution to journalReview articlepeer-review

Abstract

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. In view of this, therapies aimed at modulating the immune and inflammatory responses may represent a promising approach for limiting the optic nerve damage and the loss of retinal ganglion cells associated with glaucoma.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalNeural Regeneration Research
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • glaucoma
  • immune response
  • inflammasome
  • microglia
  • neurodegeneration
  • neuroinflammation
  • oxidative stress
  • retinal ganglion cells

ASJC Scopus subject areas

  • Developmental Neuroscience

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