Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1338-1347 |
| Number of pages | 10 |
| Journal | Neurology |
| Volume | 89 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2017 |
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Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. / Rossi, S; Studer, V; Motta, C; Polidoro, S; Perugini, J; Macchiarulo, G; Giovannetti, AM; Pareja-Gutierrez, L; Calò, A; Colonna, I; Furlan, R; Martino, G; Centonze, D.
In: Neurology, Vol. 89, No. 13, 2017, p. 1338-1347.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis
AU - Rossi, S
AU - Studer, V
AU - Motta, C
AU - Polidoro, S
AU - Perugini, J
AU - Macchiarulo, G
AU - Giovannetti, AM
AU - Pareja-Gutierrez, L
AU - Calò, A
AU - Colonna, I
AU - Furlan, R
AU - Martino, G
AU - Centonze, D
PY - 2017
Y1 - 2017
N2 - OBJECTIVE: To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS: Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BDI-II) and State/Trait Anxiety Inventory (STAI-Y). The inflammatory activity level was assessed by MRI. In a subset of 111 treatment-naive patients, CSF levels of proinflammatory cytokines were determined. Correlation and regression analyses were performed to determine associations between variables. RESULTS: Relapsing patients demonstrated greater values of STAI-state and BDI-II compared with remitting patients but comparable trait-anxiety scores. There were no significant differences in psychometric parameters between relapsing and asymptomatic MRI-active patients, highlighting the effect of subclinical inflammation on mood disturbances. A significant reduction of STAI-state and BDI-II scores was recorded, along with the subsiding of neuroinflammation. Interleukin-2 CSF levels were found to correlate with STAI-state, while tumor necrosis factor-α and interleukin-1β correlated with BDI-II. Because emotional disorders were associated with subclinical inflammation, variations of the psychometric profile were able to detect subclinical reactivation earlier. In line with this, high STAI-state values considerably predicted the possibility of disease reactivation. CONCLUSIONS: Mood alterations are induced by intrathecal inflammation, even though not clinically apparent, and are able to predict inflammatory reactivations in RRMS. Inflammation is therefore a biological event, not less important than the traditional psychosocial factors, involved in mood disorders. © 2017 American Academy of Neurology.
AB - OBJECTIVE: To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS: Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BDI-II) and State/Trait Anxiety Inventory (STAI-Y). The inflammatory activity level was assessed by MRI. In a subset of 111 treatment-naive patients, CSF levels of proinflammatory cytokines were determined. Correlation and regression analyses were performed to determine associations between variables. RESULTS: Relapsing patients demonstrated greater values of STAI-state and BDI-II compared with remitting patients but comparable trait-anxiety scores. There were no significant differences in psychometric parameters between relapsing and asymptomatic MRI-active patients, highlighting the effect of subclinical inflammation on mood disturbances. A significant reduction of STAI-state and BDI-II scores was recorded, along with the subsiding of neuroinflammation. Interleukin-2 CSF levels were found to correlate with STAI-state, while tumor necrosis factor-α and interleukin-1β correlated with BDI-II. Because emotional disorders were associated with subclinical inflammation, variations of the psychometric profile were able to detect subclinical reactivation earlier. In line with this, high STAI-state values considerably predicted the possibility of disease reactivation. CONCLUSIONS: Mood alterations are induced by intrathecal inflammation, even though not clinically apparent, and are able to predict inflammatory reactivations in RRMS. Inflammation is therefore a biological event, not less important than the traditional psychosocial factors, involved in mood disorders. © 2017 American Academy of Neurology.
U2 - 10.1212/WNL.0000000000004411
DO - 10.1212/WNL.0000000000004411
M3 - Article
VL - 89
SP - 1338
EP - 1347
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 13
ER -