Neuroinflammation imaging markers for epileptogenesis

Matthias J. Koepp, Eric Årstad, Jens P. Bankstahl, Stefanie Dedeurwaerdere, Alon Friedman, Heidrun Potschka, Teresa Ravizza, William H. Theodore, Tallie Z. Baram

Research output: Contribution to journalArticlepeer-review

Abstract

Epilepsy can be a devastating disorder. In addition to debilitating seizures, epilepsy can cause cognitive and emotional problems with reduced quality of life. Therefore, the major aim is to prevent the disorder in the first place: identify, detect, and reverse the processes responsible for its onset, and monitor and treat its progression. Epilepsy often occurs following a latent period of months to years (epileptogenesis) as a consequence of a brain insult, such as head trauma, stroke, or status epilepticus. Although this latent period clearly represents a therapeutic window, we are not able to stratify patients at risk for long-term epilepsy, which is prerequisite for preventative clinical trials. Moreover, because of the length of the latent period, an early biomarker for treatment response would be of high value. Finally, mechanistic biomarkers of epileptogenesis may provide more profound insight in the process of disease development.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalEpilepsia
Volume58
DOIs
Publication statusPublished - Jul 1 2017

Keywords

  • Blood–brain barrier
  • Epileptogenesis
  • Glia
  • Magnetic resonance imaging (MRI)
  • Nuclear medicine imaging (PET/SPECT)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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