Neurological abnormalities in full-term asphyxiated newborns and salivary S100B testing

The "Cooperative Multitask against Brain Injury of Neonates " (CoMBINe) international study

Diego Gazzolo, Francesca Pluchinotta, Moataza Bashir, Hanna Aboulgar, Hala Mufeed Said, Iskander Iman, Giorgio Ivani, Alessandra Conio, Lucia Gabriella Tina, Francesco Nigro, Giovanni Li Volti, Fabio Galvano, Fabrizio Michetti, Romolo Di Iorio, Emanuela Marinoni, Luc J. Zimmermann, Antonio D W Gavilanes, Hans J S Vles, Maria Kornacka, Darek Gruszfeld & 6 others Rosanna Frulio, Renata Sacchi, Sabina Ciotti, Francesco M. Risso, Andrea Sannia, Pasquale Florio

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Perinatal asphyxia (PA) is a leading cause of mortality and morbidity in newborns: its prognosis depends both on the severity of the asphyxia and on the immediate resuscitation to restore oxygen supply and blood circulation. Therefore, we investigated whether measurement of S100B, a consolidated marker of brain injury, in salivary fluid of PA newborns may constitute a useful tool for the early detection of asphyxia-related brain injury. Methods: We conducted a cross-sectional study in 292 full-term newborns admitted to our NICUs, of whom 48 suffered PA and 244 healthy controls admitted at our NICUs. Saliva S100B levels measurement longitudinally after birth; routine laboratory variables, neurological patterns, cerebral ultrasound and, magnetic resonance imaging were performed. The primary endpoint was the presence of neurological abnormalities at 12-months after birth. Results: S100B salivary levels were significantly (P3.25 MoM S100B achieved a sensitivity of 100% (CI5-95%: 89.3%-100%) and a specificity of 100% (CI5-95%: 98.6%-100%) as a single marker for predicting the occurrence of abnormal neurological outcome (area under the ROC curve: 1.000; CI5-95%: 0.987-1.0). Conclusions: S100B protein measurement in saliva, soon after birth, is a useful tool to identify which asphyxiated infants are at risk of neurological sequelae.

Original languageEnglish
Article numbere0115194
JournalPLoS One
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 8 2015

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asphyxia
Asphyxia
Brain Injuries
cooperatives
Brain
neonates
Newborn Infant
Resuscitation
Oxygen supply
brain
Level measurement
Hemodynamics
Testing
Magnetic resonance
Parturition
saliva
Saliva
Ultrasonics
testing
Imaging techniques

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Neurological abnormalities in full-term asphyxiated newborns and salivary S100B testing : The "Cooperative Multitask against Brain Injury of Neonates " (CoMBINe) international study. / Gazzolo, Diego; Pluchinotta, Francesca; Bashir, Moataza; Aboulgar, Hanna; Said, Hala Mufeed; Iman, Iskander; Ivani, Giorgio; Conio, Alessandra; Tina, Lucia Gabriella; Nigro, Francesco; Li Volti, Giovanni; Galvano, Fabio; Michetti, Fabrizio; Di Iorio, Romolo; Marinoni, Emanuela; Zimmermann, Luc J.; Gavilanes, Antonio D W; Vles, Hans J S; Kornacka, Maria; Gruszfeld, Darek; Frulio, Rosanna; Sacchi, Renata; Ciotti, Sabina; Risso, Francesco M.; Sannia, Andrea; Florio, Pasquale.

In: PLoS One, Vol. 10, No. 1, e0115194, 08.01.2015.

Research output: Contribution to journalArticle

Gazzolo, D, Pluchinotta, F, Bashir, M, Aboulgar, H, Said, HM, Iman, I, Ivani, G, Conio, A, Tina, LG, Nigro, F, Li Volti, G, Galvano, F, Michetti, F, Di Iorio, R, Marinoni, E, Zimmermann, LJ, Gavilanes, ADW, Vles, HJS, Kornacka, M, Gruszfeld, D, Frulio, R, Sacchi, R, Ciotti, S, Risso, FM, Sannia, A & Florio, P 2015, 'Neurological abnormalities in full-term asphyxiated newborns and salivary S100B testing: The "Cooperative Multitask against Brain Injury of Neonates " (CoMBINe) international study', PLoS One, vol. 10, no. 1, e0115194. https://doi.org/10.1371/journal.pone.0115194
Gazzolo, Diego ; Pluchinotta, Francesca ; Bashir, Moataza ; Aboulgar, Hanna ; Said, Hala Mufeed ; Iman, Iskander ; Ivani, Giorgio ; Conio, Alessandra ; Tina, Lucia Gabriella ; Nigro, Francesco ; Li Volti, Giovanni ; Galvano, Fabio ; Michetti, Fabrizio ; Di Iorio, Romolo ; Marinoni, Emanuela ; Zimmermann, Luc J. ; Gavilanes, Antonio D W ; Vles, Hans J S ; Kornacka, Maria ; Gruszfeld, Darek ; Frulio, Rosanna ; Sacchi, Renata ; Ciotti, Sabina ; Risso, Francesco M. ; Sannia, Andrea ; Florio, Pasquale. / Neurological abnormalities in full-term asphyxiated newborns and salivary S100B testing : The "Cooperative Multitask against Brain Injury of Neonates " (CoMBINe) international study. In: PLoS One. 2015 ; Vol. 10, No. 1.
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T2 - The "Cooperative Multitask against Brain Injury of Neonates " (CoMBINe) international study

AU - Gazzolo, Diego

AU - Pluchinotta, Francesca

AU - Bashir, Moataza

AU - Aboulgar, Hanna

AU - Said, Hala Mufeed

AU - Iman, Iskander

AU - Ivani, Giorgio

AU - Conio, Alessandra

AU - Tina, Lucia Gabriella

AU - Nigro, Francesco

AU - Li Volti, Giovanni

AU - Galvano, Fabio

AU - Michetti, Fabrizio

AU - Di Iorio, Romolo

AU - Marinoni, Emanuela

AU - Zimmermann, Luc J.

AU - Gavilanes, Antonio D W

AU - Vles, Hans J S

AU - Kornacka, Maria

AU - Gruszfeld, Darek

AU - Frulio, Rosanna

AU - Sacchi, Renata

AU - Ciotti, Sabina

AU - Risso, Francesco M.

AU - Sannia, Andrea

AU - Florio, Pasquale

PY - 2015/1/8

Y1 - 2015/1/8

N2 - Background: Perinatal asphyxia (PA) is a leading cause of mortality and morbidity in newborns: its prognosis depends both on the severity of the asphyxia and on the immediate resuscitation to restore oxygen supply and blood circulation. Therefore, we investigated whether measurement of S100B, a consolidated marker of brain injury, in salivary fluid of PA newborns may constitute a useful tool for the early detection of asphyxia-related brain injury. Methods: We conducted a cross-sectional study in 292 full-term newborns admitted to our NICUs, of whom 48 suffered PA and 244 healthy controls admitted at our NICUs. Saliva S100B levels measurement longitudinally after birth; routine laboratory variables, neurological patterns, cerebral ultrasound and, magnetic resonance imaging were performed. The primary endpoint was the presence of neurological abnormalities at 12-months after birth. Results: S100B salivary levels were significantly (P3.25 MoM S100B achieved a sensitivity of 100% (CI5-95%: 89.3%-100%) and a specificity of 100% (CI5-95%: 98.6%-100%) as a single marker for predicting the occurrence of abnormal neurological outcome (area under the ROC curve: 1.000; CI5-95%: 0.987-1.0). Conclusions: S100B protein measurement in saliva, soon after birth, is a useful tool to identify which asphyxiated infants are at risk of neurological sequelae.

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