Abstract
In children and adolescents suffering from Crigler-Najjar syndrome type I, the most worrisome complication is the possible appearance of neurological disorders with aging. We report the results of a neurological and neurophysiological assessment in 6 patients (age range 5-26 years) suffering from Crigler-Najjar syndrome type I. Our results indicate that, in children and adolescents with Crigler-Najjar syndrome type I, neurophysiological tests, such as EEG-polygraphic recordings, are sensitive techniques to demonstrate the involvement of the central nervous system and to evaluate the efficacy of the treatment (i.e., liver transplantation in one of our patients), therefore suggesting a possible usefulness of these neurophysiological techniques for the timing of liver transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 95-98 |
| Number of pages | 4 |
| Journal | Gastroenterology International |
| Volume | 12 |
| Issue number | 2 |
| Publication status | Published - 1999 |
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Keywords
- Crigler-Najjar syndrome
- EEG
- Kernicterus
- Liver transplantation
ASJC Scopus subject areas
- Gastroenterology
Cite this
Neurological and neurophysiological follow-up in patients with Crigler-Najjar syndrome type I and possible implications for the timing of liver transplantation. / Rubboli, G.; Ronchi, F.; Cecchi, P.; Meletti, S.; Gardella, E.; Zaniboni, A.; D'Orsi, G.; Testoni, S.; Bisulli, A.; Tassinari, C. A.
In: Gastroenterology International, Vol. 12, No. 2, 1999, p. 95-98.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurological and neurophysiological follow-up in patients with Crigler-Najjar syndrome type I and possible implications for the timing of liver transplantation
AU - Rubboli, G.
AU - Ronchi, F.
AU - Cecchi, P.
AU - Meletti, S.
AU - Gardella, E.
AU - Zaniboni, A.
AU - D'Orsi, G.
AU - Testoni, S.
AU - Bisulli, A.
AU - Tassinari, C. A.
PY - 1999
Y1 - 1999
N2 - In children and adolescents suffering from Crigler-Najjar syndrome type I, the most worrisome complication is the possible appearance of neurological disorders with aging. We report the results of a neurological and neurophysiological assessment in 6 patients (age range 5-26 years) suffering from Crigler-Najjar syndrome type I. Our results indicate that, in children and adolescents with Crigler-Najjar syndrome type I, neurophysiological tests, such as EEG-polygraphic recordings, are sensitive techniques to demonstrate the involvement of the central nervous system and to evaluate the efficacy of the treatment (i.e., liver transplantation in one of our patients), therefore suggesting a possible usefulness of these neurophysiological techniques for the timing of liver transplantation.
AB - In children and adolescents suffering from Crigler-Najjar syndrome type I, the most worrisome complication is the possible appearance of neurological disorders with aging. We report the results of a neurological and neurophysiological assessment in 6 patients (age range 5-26 years) suffering from Crigler-Najjar syndrome type I. Our results indicate that, in children and adolescents with Crigler-Najjar syndrome type I, neurophysiological tests, such as EEG-polygraphic recordings, are sensitive techniques to demonstrate the involvement of the central nervous system and to evaluate the efficacy of the treatment (i.e., liver transplantation in one of our patients), therefore suggesting a possible usefulness of these neurophysiological techniques for the timing of liver transplantation.
KW - Crigler-Najjar syndrome
KW - EEG
KW - Kernicterus
KW - Liver transplantation
UR - http://www.scopus.com/inward/record.url?scp=0032858749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032858749&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0032858749
VL - 12
SP - 95
EP - 98
JO - Gastroenterology International
JF - Gastroenterology International
SN - 0950-5911
IS - 2
ER -