Neurological complications in hyperemesis gravidarum

Gabriella Zara, Valentina Codemo, Arianna Palmieri, Sami Schiff, Annachiara Cagnin, Valentina Citton, Renzo Manara

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Hyperemesis gravidarum can impair correct absorption of an adequate amount of thiamine and can cause electrolyte imbalance. This study investigated the neurological complications in a pregnant woman with hyperemesis gravidarum. A 29-year-old pregnant woman was admitted for hyperemesis gravidarum. Besides undernutrition, a neurological examination disclosed weakness with hyporeflexia, ophthalmoparesis, multidirectional nystagmus and optic disks swelling; the patient became rapidly comatose. Brain MRI showed symmetric signal hyperintensity and swelling of periaqueductal area, hypothalamus and mammillary bodies, medial and posterior portions of the thalamus and columns of fornix, consistent with Wernicke encephalopathy (WE). Neurophysiological studies revealed an axonal sensory-motor polyneuropathy, likely due to thiamine deficiency or critical illness polyneuropathy. Sodium and potassium supplementation and parenteral thiamine were administered with improvement of consciousness state in a few days. WE evolved in Korsakoff syndrome. A repeat MRI showed a marked improvement of WE-related alterations and a new hyperintense lesion in the pons, suggestive of central pontine myelinolysis. No sign or symptom due to involvement of the pons was present.

Original languageEnglish
Pages (from-to)133-135
Number of pages3
JournalNeurological Sciences
Volume33
Issue number1
DOIs
Publication statusPublished - Feb 2012

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Hyperemesis Gravidarum
Wernicke Encephalopathy
Pons
Polyneuropathies
Thiamine
Pregnant Women
Central Pontine Myelinolysis
Korsakoff Syndrome
Mammillary Bodies
Thiamine Deficiency
Pathologic Nystagmus
Ophthalmoplegia
Abnormal Reflexes
Optic Disk
Neurologic Examination
Coma
Consciousness
Thalamus
Malnutrition
Electrolytes

Keywords

  • Central pontine myelinolysis
  • Hyperemesis gravidarum
  • Korsakoff syndrome
  • Thiamine deficiency
  • Wernicke encephalopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

Cite this

Zara, G., Codemo, V., Palmieri, A., Schiff, S., Cagnin, A., Citton, V., & Manara, R. (2012). Neurological complications in hyperemesis gravidarum. Neurological Sciences, 33(1), 133-135. https://doi.org/10.1007/s10072-011-0660-y

Neurological complications in hyperemesis gravidarum. / Zara, Gabriella; Codemo, Valentina; Palmieri, Arianna; Schiff, Sami; Cagnin, Annachiara; Citton, Valentina; Manara, Renzo.

In: Neurological Sciences, Vol. 33, No. 1, 02.2012, p. 133-135.

Research output: Contribution to journalArticle

Zara, G, Codemo, V, Palmieri, A, Schiff, S, Cagnin, A, Citton, V & Manara, R 2012, 'Neurological complications in hyperemesis gravidarum', Neurological Sciences, vol. 33, no. 1, pp. 133-135. https://doi.org/10.1007/s10072-011-0660-y
Zara G, Codemo V, Palmieri A, Schiff S, Cagnin A, Citton V et al. Neurological complications in hyperemesis gravidarum. Neurological Sciences. 2012 Feb;33(1):133-135. https://doi.org/10.1007/s10072-011-0660-y
Zara, Gabriella ; Codemo, Valentina ; Palmieri, Arianna ; Schiff, Sami ; Cagnin, Annachiara ; Citton, Valentina ; Manara, Renzo. / Neurological complications in hyperemesis gravidarum. In: Neurological Sciences. 2012 ; Vol. 33, No. 1. pp. 133-135.
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