Neurological disorders and inflammatory bowel diseases

Giovanni Casella, Gian Eugenio Tontini, Gabrio Bassotti, Luca Pastorelli, Vincenzo Villanacci, Luisa Spina, Vittorio Baldini, Maurizio Vecchi

Research output: Contribution to journalArticle


Extraintestinal manifestations occur in about one-third of patients living with inflammatory bowel disease (IBD) and may precede the onset of gastrointestinal symptoms by many years. Neurologic disorders associated with IBD are not frequent, being reported in 3% of patients, but they often represent an important cause of morbidity and a relevant diagnostic issue. In addition, the increasing use of immunosuppressant and biological therapies for IBD may also play a pivotal role in the development of neurological disorders of different type and pathogenesis. Hence, we provide a complete and profound review of the main features of neurological complications associated with IBD, with particular reference to those related to drugs and with a specific focus on their clinical presentation and possible pathophysiological mechanisms.

Original languageEnglish
Pages (from-to)8764-8782
Number of pages19
JournalWorld Journal of Gastroenterology
Issue number27
Publication statusPublished - Jul 21 2014



  • Cerebrovascular diseases
  • Crohn's disease
  • Demyelinating neuropathies
  • Extraintestinal manifestations
  • Inflammatory bowel diseases
  • Multiple sclerosis
  • Neurological disorders
  • Progressive multifocal encephalopathy
  • Side effects
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Casella, G., Tontini, G. E., Bassotti, G., Pastorelli, L., Villanacci, V., Spina, L., Baldini, V., & Vecchi, M. (2014). Neurological disorders and inflammatory bowel diseases. World Journal of Gastroenterology, (27), 8764-8782.