Neurological disorders, other than stroke, associated with antiphospholipid antibodies in childhood

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Abstract

We report the results of a systematic study on the association of antiphospholipid antibodies (aPLs) with some neurological diseases other than stroke in a childhood population. Patients affected by migraine, benign intracranial hyper-tension (BIH) or unilateral movement disorders, such as hemichorea and hemidystonia with acute-subacute onset, were screened for aPLs. None of them had clinical or serological evidence of Systemic Lupus Erythematosus (SLE) or other connective tissue disease. Moderate to high levels of anticardiolipin antibodies (aCL) and/or positive Lupus Anticoagulant (LA) were demonstrated in 6 out of 17 patients with migraine, in 3 out of 4 patients with BIH and in all of the 5 patients showing unilateral movement disorders. The association between aPLs and these neurological conditions, usually regarded as cryptogenic, may suggest a possible pathogenetic mechanism.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalNeuropediatrics
Volume27
Issue number3
Publication statusPublished - Jun 1996

Keywords

  • Antiphospholipid antibodies
  • Benign intracranial hypertension
  • Chorea
  • Hemidystonia
  • Migraine

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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