Neurological features in AIDS patients: Studies on cerebrospinal fluid

L. Ortona, E. Tamburrini, A. Antinori, G. Ventura

Research output: Contribution to journalArticlepeer-review


The relationship between cerebrospinal fluid (CSF) markers of HIV infection and the spectrum of neurological manifestations were studied in 15 AIDS patients (13 with and 2 without confirmed neurological disorders). We demonstrated the presence of intrathecally synthesized anti-HIV antibodies. Antibodies to HIV envelope proteins were present in all patients but those to HIV core proteins in 9/13 cases only. HIV antigen and HIV p24 antigen were present in 6/14 and 4/12 cases respectively. HIV was not isolated from 6 samples of CSF. We have demonstrated that CSF markers of HIV infection were present in all AIDS patients, with or without neurological manifestations. Moreover HIV p24 antigen seems to be a very reliable marker of HIV infection.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalItalian Journal of Neurological Sciences
Issue number6
Publication statusPublished - Dec 1988


  • AIDS-HIV infection
  • anti-HIV core antibodies
  • anti-HIV envelope antibodies
  • central nervous system
  • cerebrospinal fluid
  • HIV-p24 antigen
  • neurological manifestation
  • oligoclonal IgG bands
  • total intra-blood-brain-barrier IgG synthesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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