Neurological impairment and arthritis in an immunocompetent child with human parvovirus B19 chronic infection

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Human parvovirus B19 (HPV-B19) is usually a self-limiting infection in immunocompetent children. In this case report, instead, we describe an immunocompotent child with evidence of persistent HPV-B19 infection, arthritis and neurological impairment. He was first admitted to hospital for HPV-B19 infection and sent home in good clinical condition after anti-inflammatory therapy. Eight months later he was re-admitted to hospital for episodes of arthritis and weakness, myalgia, tremors in his legs and hands, and was unable to walk unaided. In both plasma and serum, HPV-B19 DNA, detected by polymerase chain reaction, was still present. For neurological symptoms, he underwent magnetic resonance, which showed increased signal intensity at the spinal roots in the lumbar region, compatible with polyradiculoneuritis. After immunoglobulin therapy he had an excellent response in clinical and radiological terms, suggesting an association between neurological impairment and HPV-B19 infection. Eleven months after the second admission, the patient was still in good clinical condition.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalInfezioni in Medicina
Volume18
Issue number3
Publication statusPublished - Sep 2010

Fingerprint

Human Parvovirus B19
Arthritis
Parvoviridae Infections
Infection
Polyradiculoneuropathy
Lumbosacral Region
Passive Immunization
Spinal Nerve Roots
Patient Admission
Myalgia
Tremor
DNA-Directed DNA Polymerase
Leg
Anti-Inflammatory Agents
Magnetic Resonance Spectroscopy
Hand
Polymerase Chain Reaction
Serum

Keywords

  • Arthritis
  • Children
  • Human parvovirus B19
  • Neurological impairment

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Neurological impairment and arthritis in an immunocompetent child with human parvovirus B19 chronic infection. / Bozzola, Elena; Krzysztofiak, Andrzej; Cortis, Eisabetta.

In: Infezioni in Medicina, Vol. 18, No. 3, 09.2010, p. 187-190.

Research output: Contribution to journalArticle

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