Abstract
A wide variety of neurological and/or psychiatric disturbances has been reported in patients surviving the acute phase of carbon monoxide (CO) poi soning, after a period of apparent recovery. Postulated pathogenic mecha nisms of these sequelae, usually referred to as 'delayed neurological syndrome' (DNS) include: (1) hypoxic-ischemic stress related to defective oxygen trans port to the cells and to impaired cardiovascular function; (2) CO interaction with intracellular targets (e.g. cytochromes) with impairment of mitochondrial electron transport; (3) brain lipid peroxidation; (4) excessive stimulation of excitatory amino acid receptors. Timely hyperbaric oxygen (HBO) treatment may interrupt the cascade of events leading to brain damage, and has been advocated as effective in preventing DNS. However, clinical studies compar ing the efficacy of hyperbaric versus normobaric oxygen have generated con flicting results and controversies regarding both the causes of delayed CO neu rotoxicity and the indications of HBO therapy. Additional clinical investiga tions and further basic research using appropriate animal models are needed.
| Original language | English |
|---|---|
| Pages (from-to) | 134-139 |
| Number of pages | 6 |
| Journal | Indoor and Built Environment |
| Volume | 4 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- Brain diseases (chemically induced)
- Carbon monoxide
- Delayed neurological syndrome
- Hyperbaric oxygen
- Normobaric oxygen
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Neurological Sequelae of Carbon Monoxide Poisoning : Role of Hyperbaric Oxygen. / Butera, Raffaella; Candura, Stefano M.; Locatelli, Carlo; Varango, Concettina; Li, Bin; Manzo, Luigi.
In: Indoor and Built Environment, Vol. 4, No. 3-4, 1995, p. 134-139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurological Sequelae of Carbon Monoxide Poisoning
T2 - Role of Hyperbaric Oxygen
AU - Butera, Raffaella
AU - Candura, Stefano M.
AU - Locatelli, Carlo
AU - Varango, Concettina
AU - Li, Bin
AU - Manzo, Luigi
PY - 1995
Y1 - 1995
N2 - A wide variety of neurological and/or psychiatric disturbances has been reported in patients surviving the acute phase of carbon monoxide (CO) poi soning, after a period of apparent recovery. Postulated pathogenic mecha nisms of these sequelae, usually referred to as 'delayed neurological syndrome' (DNS) include: (1) hypoxic-ischemic stress related to defective oxygen trans port to the cells and to impaired cardiovascular function; (2) CO interaction with intracellular targets (e.g. cytochromes) with impairment of mitochondrial electron transport; (3) brain lipid peroxidation; (4) excessive stimulation of excitatory amino acid receptors. Timely hyperbaric oxygen (HBO) treatment may interrupt the cascade of events leading to brain damage, and has been advocated as effective in preventing DNS. However, clinical studies compar ing the efficacy of hyperbaric versus normobaric oxygen have generated con flicting results and controversies regarding both the causes of delayed CO neu rotoxicity and the indications of HBO therapy. Additional clinical investiga tions and further basic research using appropriate animal models are needed.
AB - A wide variety of neurological and/or psychiatric disturbances has been reported in patients surviving the acute phase of carbon monoxide (CO) poi soning, after a period of apparent recovery. Postulated pathogenic mecha nisms of these sequelae, usually referred to as 'delayed neurological syndrome' (DNS) include: (1) hypoxic-ischemic stress related to defective oxygen trans port to the cells and to impaired cardiovascular function; (2) CO interaction with intracellular targets (e.g. cytochromes) with impairment of mitochondrial electron transport; (3) brain lipid peroxidation; (4) excessive stimulation of excitatory amino acid receptors. Timely hyperbaric oxygen (HBO) treatment may interrupt the cascade of events leading to brain damage, and has been advocated as effective in preventing DNS. However, clinical studies compar ing the efficacy of hyperbaric versus normobaric oxygen have generated con flicting results and controversies regarding both the causes of delayed CO neu rotoxicity and the indications of HBO therapy. Additional clinical investiga tions and further basic research using appropriate animal models are needed.
KW - Brain diseases (chemically induced)
KW - Carbon monoxide
KW - Delayed neurological syndrome
KW - Hyperbaric oxygen
KW - Normobaric oxygen
UR - http://www.scopus.com/inward/record.url?scp=84964116608&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964116608&partnerID=8YFLogxK
U2 - 10.1177/1420326X9500400302
DO - 10.1177/1420326X9500400302
M3 - Article
AN - SCOPUS:84964116608
VL - 4
SP - 134
EP - 139
JO - Indoor and Built Environment
JF - Indoor and Built Environment
SN - 1420-326X
IS - 3-4
ER -