Neurological symptoms during primary Human Immunodeficiency Virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid

G. Tambussi, A. Gori, B. Capiluppi, C. Balotta, L. Papagno, B. Morandini, M. Di Pietro, D. Ciuffreda, A. Saracco, A. Lazzarin

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

This analysis involves 22 patients with diagnosed symptomatic human immunodeficiency virus (HIV) infection. Neurologic symptoms were present in 11 patients, ranging from severe and persistent headache to clinical signs suggestive of meningitis. A strong correlation between neurological symptoms and cerebrospinal fluid (CSF) viral load was found. The mean CSF HIV ribonucleic acid (RNA) level was 4.12 log for patients with neurological symptoms and 2.58 log for patients without neurological symptoms (P <.00001). Plasma viral load alone does not correlate or predict central nervous system (CNS) involvement. In our sample of patients, HIV RNA levels could be detected in most patients regardless of the presence of neurological symptoms. Moreover, early treatment including drugs with high levels of penetration in the CNS must be considered for patients with primary HIV infection.

Original languageEnglish
Pages (from-to)962-965
Number of pages4
JournalClinical Infectious Diseases
Volume30
Issue number6
DOIs
Publication statusPublished - 2000

Fingerprint

Virus Diseases
Cerebrospinal Fluid
HIV
RNA
Viral Load
Central Nervous System
Neurologic Manifestations
Meningitis
Headache
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology

Cite this

Neurological symptoms during primary Human Immunodeficiency Virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid. / Tambussi, G.; Gori, A.; Capiluppi, B.; Balotta, C.; Papagno, L.; Morandini, B.; Di Pietro, M.; Ciuffreda, D.; Saracco, A.; Lazzarin, A.

In: Clinical Infectious Diseases, Vol. 30, No. 6, 2000, p. 962-965.

Research output: Contribution to journalArticle

Tambussi, G, Gori, A, Capiluppi, B, Balotta, C, Papagno, L, Morandini, B, Di Pietro, M, Ciuffreda, D, Saracco, A & Lazzarin, A 2000, 'Neurological symptoms during primary Human Immunodeficiency Virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid', Clinical Infectious Diseases, vol. 30, no. 6, pp. 962-965. https://doi.org/10.1086/313810
Tambussi, G. ; Gori, A. ; Capiluppi, B. ; Balotta, C. ; Papagno, L. ; Morandini, B. ; Di Pietro, M. ; Ciuffreda, D. ; Saracco, A. ; Lazzarin, A. / Neurological symptoms during primary Human Immunodeficiency Virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid. In: Clinical Infectious Diseases. 2000 ; Vol. 30, No. 6. pp. 962-965.
@article{9ac049f254684a98920762c9fbd35dbb,
title = "Neurological symptoms during primary Human Immunodeficiency Virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid",
abstract = "This analysis involves 22 patients with diagnosed symptomatic human immunodeficiency virus (HIV) infection. Neurologic symptoms were present in 11 patients, ranging from severe and persistent headache to clinical signs suggestive of meningitis. A strong correlation between neurological symptoms and cerebrospinal fluid (CSF) viral load was found. The mean CSF HIV ribonucleic acid (RNA) level was 4.12 log for patients with neurological symptoms and 2.58 log for patients without neurological symptoms (P <.00001). Plasma viral load alone does not correlate or predict central nervous system (CNS) involvement. In our sample of patients, HIV RNA levels could be detected in most patients regardless of the presence of neurological symptoms. Moreover, early treatment including drugs with high levels of penetration in the CNS must be considered for patients with primary HIV infection.",
author = "G. Tambussi and A. Gori and B. Capiluppi and C. Balotta and L. Papagno and B. Morandini and {Di Pietro}, M. and D. Ciuffreda and A. Saracco and A. Lazzarin",
year = "2000",
doi = "10.1086/313810",
language = "English",
volume = "30",
pages = "962--965",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "NLM (Medline)",
number = "6",

}

TY - JOUR

T1 - Neurological symptoms during primary Human Immunodeficiency Virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid

AU - Tambussi, G.

AU - Gori, A.

AU - Capiluppi, B.

AU - Balotta, C.

AU - Papagno, L.

AU - Morandini, B.

AU - Di Pietro, M.

AU - Ciuffreda, D.

AU - Saracco, A.

AU - Lazzarin, A.

PY - 2000

Y1 - 2000

N2 - This analysis involves 22 patients with diagnosed symptomatic human immunodeficiency virus (HIV) infection. Neurologic symptoms were present in 11 patients, ranging from severe and persistent headache to clinical signs suggestive of meningitis. A strong correlation between neurological symptoms and cerebrospinal fluid (CSF) viral load was found. The mean CSF HIV ribonucleic acid (RNA) level was 4.12 log for patients with neurological symptoms and 2.58 log for patients without neurological symptoms (P <.00001). Plasma viral load alone does not correlate or predict central nervous system (CNS) involvement. In our sample of patients, HIV RNA levels could be detected in most patients regardless of the presence of neurological symptoms. Moreover, early treatment including drugs with high levels of penetration in the CNS must be considered for patients with primary HIV infection.

AB - This analysis involves 22 patients with diagnosed symptomatic human immunodeficiency virus (HIV) infection. Neurologic symptoms were present in 11 patients, ranging from severe and persistent headache to clinical signs suggestive of meningitis. A strong correlation between neurological symptoms and cerebrospinal fluid (CSF) viral load was found. The mean CSF HIV ribonucleic acid (RNA) level was 4.12 log for patients with neurological symptoms and 2.58 log for patients without neurological symptoms (P <.00001). Plasma viral load alone does not correlate or predict central nervous system (CNS) involvement. In our sample of patients, HIV RNA levels could be detected in most patients regardless of the presence of neurological symptoms. Moreover, early treatment including drugs with high levels of penetration in the CNS must be considered for patients with primary HIV infection.

UR - http://www.scopus.com/inward/record.url?scp=0034464142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034464142&partnerID=8YFLogxK

U2 - 10.1086/313810

DO - 10.1086/313810

M3 - Article

VL - 30

SP - 962

EP - 965

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 6

ER -