Neurometabolic Profiling of Ketamine: Changes in Neurotransmitter Pools

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The need for understanding the mechanisms of ketamine action in the brain has pushed research to measure the effect of ketamine on neurotransmitters. In fact, ketamine binds to a variety of receptors, but principally acts at the N-methyl-. D-aspartate receptor (NMDAR) thus being responsible for NMDAR blockade and/or hypofunction. This hypofunction can explain connectional and oscillatory abnormalities considered as a consequence of a weakened excitation of inhibitory gamma-aminobutyric acidergic interneurons that synchronize cortical networks and disinhibition of principal cells. The chapter reviews the studies that have investigated about the changes on the neurotransmitter pools until now to provide robust evidences of the most recent theory of the action of ketamine on human and animal brain.

Original languageEnglish
Title of host publicationStimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects
PublisherElsevier Inc.
Pages573-580
Number of pages8
Volume2
ISBN (Print)9780128003756, 9780128002124
DOIs
Publication statusPublished - Apr 15 2016

Fingerprint

Ketamine
Neurotransmitter Agents
D-Aspartic Acid
Brain
Interneurons
Research

Keywords

  • Dopamine
  • GABA
  • Glutamate
  • Glutamine
  • Ketamine
  • Microdialysis
  • NMDAR
  • NMR spectroscopy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Napolitano, A., & Andellini, M. (2016). Neurometabolic Profiling of Ketamine: Changes in Neurotransmitter Pools. In Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects (Vol. 2, pp. 573-580). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800212-4.00053-4

Neurometabolic Profiling of Ketamine : Changes in Neurotransmitter Pools. / Napolitano, Antonio; Andellini, Martina.

Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. Vol. 2 Elsevier Inc., 2016. p. 573-580.

Research output: Chapter in Book/Report/Conference proceedingChapter

Napolitano, A & Andellini, M 2016, Neurometabolic Profiling of Ketamine: Changes in Neurotransmitter Pools. in Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. vol. 2, Elsevier Inc., pp. 573-580. https://doi.org/10.1016/B978-0-12-800212-4.00053-4
Napolitano A, Andellini M. Neurometabolic Profiling of Ketamine: Changes in Neurotransmitter Pools. In Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. Vol. 2. Elsevier Inc. 2016. p. 573-580 https://doi.org/10.1016/B978-0-12-800212-4.00053-4
Napolitano, Antonio ; Andellini, Martina. / Neurometabolic Profiling of Ketamine : Changes in Neurotransmitter Pools. Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. Vol. 2 Elsevier Inc., 2016. pp. 573-580
@inbook{1436a3fdd06f4b93b8bfa2f5948bf889,
title = "Neurometabolic Profiling of Ketamine: Changes in Neurotransmitter Pools",
abstract = "The need for understanding the mechanisms of ketamine action in the brain has pushed research to measure the effect of ketamine on neurotransmitters. In fact, ketamine binds to a variety of receptors, but principally acts at the N-methyl-. D-aspartate receptor (NMDAR) thus being responsible for NMDAR blockade and/or hypofunction. This hypofunction can explain connectional and oscillatory abnormalities considered as a consequence of a weakened excitation of inhibitory gamma-aminobutyric acidergic interneurons that synchronize cortical networks and disinhibition of principal cells. The chapter reviews the studies that have investigated about the changes on the neurotransmitter pools until now to provide robust evidences of the most recent theory of the action of ketamine on human and animal brain.",
keywords = "Dopamine, GABA, Glutamate, Glutamine, Ketamine, Microdialysis, NMDAR, NMR spectroscopy",
author = "Antonio Napolitano and Martina Andellini",
year = "2016",
month = "4",
day = "15",
doi = "10.1016/B978-0-12-800212-4.00053-4",
language = "English",
isbn = "9780128003756",
volume = "2",
pages = "573--580",
booktitle = "Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Neurometabolic Profiling of Ketamine

T2 - Changes in Neurotransmitter Pools

AU - Napolitano, Antonio

AU - Andellini, Martina

PY - 2016/4/15

Y1 - 2016/4/15

N2 - The need for understanding the mechanisms of ketamine action in the brain has pushed research to measure the effect of ketamine on neurotransmitters. In fact, ketamine binds to a variety of receptors, but principally acts at the N-methyl-. D-aspartate receptor (NMDAR) thus being responsible for NMDAR blockade and/or hypofunction. This hypofunction can explain connectional and oscillatory abnormalities considered as a consequence of a weakened excitation of inhibitory gamma-aminobutyric acidergic interneurons that synchronize cortical networks and disinhibition of principal cells. The chapter reviews the studies that have investigated about the changes on the neurotransmitter pools until now to provide robust evidences of the most recent theory of the action of ketamine on human and animal brain.

AB - The need for understanding the mechanisms of ketamine action in the brain has pushed research to measure the effect of ketamine on neurotransmitters. In fact, ketamine binds to a variety of receptors, but principally acts at the N-methyl-. D-aspartate receptor (NMDAR) thus being responsible for NMDAR blockade and/or hypofunction. This hypofunction can explain connectional and oscillatory abnormalities considered as a consequence of a weakened excitation of inhibitory gamma-aminobutyric acidergic interneurons that synchronize cortical networks and disinhibition of principal cells. The chapter reviews the studies that have investigated about the changes on the neurotransmitter pools until now to provide robust evidences of the most recent theory of the action of ketamine on human and animal brain.

KW - Dopamine

KW - GABA

KW - Glutamate

KW - Glutamine

KW - Ketamine

KW - Microdialysis

KW - NMDAR

KW - NMR spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84969668294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969668294&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-800212-4.00053-4

DO - 10.1016/B978-0-12-800212-4.00053-4

M3 - Chapter

AN - SCOPUS:84969668294

SN - 9780128003756

SN - 9780128002124

VL - 2

SP - 573

EP - 580

BT - Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects

PB - Elsevier Inc.

ER -