Neurometabolic Profiling of Ketamine: Changes in Neurotransmitter Pools

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The need for understanding the mechanisms of ketamine action in the brain has pushed research to measure the effect of ketamine on neurotransmitters. In fact, ketamine binds to a variety of receptors, but principally acts at the N-methyl-. D-aspartate receptor (NMDAR) thus being responsible for NMDAR blockade and/or hypofunction. This hypofunction can explain connectional and oscillatory abnormalities considered as a consequence of a weakened excitation of inhibitory gamma-aminobutyric acidergic interneurons that synchronize cortical networks and disinhibition of principal cells. The chapter reviews the studies that have investigated about the changes on the neurotransmitter pools until now to provide robust evidences of the most recent theory of the action of ketamine on human and animal brain.

Original languageEnglish
Title of host publicationStimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects
PublisherElsevier Inc.
Pages573-580
Number of pages8
Volume2
ISBN (Print)9780128003756, 9780128002124
DOIs
Publication statusPublished - Apr 15 2016

Keywords

  • Dopamine
  • GABA
  • Glutamate
  • Glutamine
  • Ketamine
  • Microdialysis
  • NMDAR
  • NMR spectroscopy

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Napolitano, A., & Andellini, M. (2016). Neurometabolic Profiling of Ketamine: Changes in Neurotransmitter Pools. In Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects (Vol. 2, pp. 573-580). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800212-4.00053-4