Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

Annamaria Vezzani, Barbara Viviani

Research output: Contribution to journalArticle

Abstract

Abstract Increasing evidence underlines that prototypical inflammatory cytokines (IL-1β, TNF-α and IL-6) either synthesized in the central (CNS) or peripheral nervous system (PNS) by resident cells, or imported by immune blood cells, are involved in several pathophysiological functions, including an unexpected impact on synaptic transmission and neuronal excitability. This review describes these unconventional neuromodulatory properties of cytokines, that are distinct from their classical action as effector molecules of the immune system. In addition to the role of cytokines in brain physiology, we report evidence that dysregulation of their biosynthesis and cellular release, or alterations in receptor-mediated intracellular pathways in target cells, leads to neuronal cell dysfunction and modifications in neuronal network excitability. As a consequence, targeting of these cytokines, and related signalling molecules, is considered a novel option for the development of therapies in various CNS or PNS disorders associated with an inflammatory component. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'.

Original languageEnglish
Article number5646
Pages (from-to)70-82
Number of pages13
JournalNeuropharmacology
Issue numberPart A
DOIs
Publication statusPublished - Jun 16 2015

Keywords

  • Blood-brain barrier
  • Channelopathy
  • Cognition
  • Epilepsy
  • Glia
  • Glutamate and GABA receptors
  • Innate immunity
  • Neuroinflammation
  • Neuropathology
  • Synaptic transmission

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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