Neuromuscular transmission in migraine patients with prolonged aura

A. Ambrosini, A. M. De Noordhout, J. Schoenen

Research output: Contribution to journalArticlepeer-review


P/Q Ca2+ channels are genetically abnormal in most cases of familial hemiplegic migraine (FHM) and may be involved in other types of migraine. They are also found at the neuromuscular junctions, where they control stimulation-induced acetylcholine release. Prolonged aura is a very frequent clinical feature in FHM patients. The objective of this study was thus to explore neuromuscular transmission in migraine with typical and prolonged aura patients. We performed single fiber electromyography (SFEMG) in such patients and compared them to a group of healthy volunteers. Results were expressed as mean jitter (MCD) and percentage of single endplate abnormalities. Mean MCD was on average comparable in controls and migraineurs. By contrast, single endplate abnormalities were only found in patients (p2+-channels.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalActa Neurologica Belgica
Issue number3
Publication statusPublished - 2001


  • Familial hemiplegic migraine
  • Migraine
  • Neuromascular transmission
  • Prolonged aura
  • Single fiber electromyography

ASJC Scopus subject areas

  • Clinical Neurology


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