Neuromyelitis optica in patients with myasthenia gravis who underwent thymectomy

Ilya Kister, Sandeep Gulati, Cavit Boz, Roberto Bergamaschi, Guiseppe Piccolo, Joel Oger, Michael L. Swerdlow

Research output: Contribution to journalArticle

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Abstract

Background: Myasthenia gravis (MG) and neuromyelitis optica (NMO, also known as Devic disease) are rare autoimmune disorders, with upper-limit prevalence estimates in the general population of 15 per 100 000 and 5 per 100 000, respectively. To our knowledge, an association between these diseases has not been previously reported. Objectives: To describe 4 patients with MG who developed NMO after thymectomy and to analyze possible causes of apparent increased prevalence of NMO among patients with MG. Design: Case series. Patients: Four patients with MG who underwent thymectomy. Interventions: None. Results: The prevalence ofMGwithin the published cohort of patients withNMOis more than 150 times higher than that in the general population. Conclusion: Dysregulation of B-cell autoimmunity in myasthenia, possibly exacerbated by loss of control over autoreactive cells as a result of thymectomy, may predispose patients to the development of NMO.

Original languageEnglish
Pages (from-to)851-856
Number of pages6
JournalArchives of Neurology
Volume63
Issue number6
DOIs
Publication statusPublished - 2006

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Neuromyelitis Optica
Thymectomy
Myasthenia Gravis
Autoimmunity
Population
B-Lymphocytes

ASJC Scopus subject areas

  • Neuroscience(all)

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Neuromyelitis optica in patients with myasthenia gravis who underwent thymectomy. / Kister, Ilya; Gulati, Sandeep; Boz, Cavit; Bergamaschi, Roberto; Piccolo, Guiseppe; Oger, Joel; Swerdlow, Michael L.

In: Archives of Neurology, Vol. 63, No. 6, 2006, p. 851-856.

Research output: Contribution to journalArticle

Kister, I, Gulati, S, Boz, C, Bergamaschi, R, Piccolo, G, Oger, J & Swerdlow, ML 2006, 'Neuromyelitis optica in patients with myasthenia gravis who underwent thymectomy', Archives of Neurology, vol. 63, no. 6, pp. 851-856. https://doi.org/10.1001/archneur.63.6.851
Kister, Ilya ; Gulati, Sandeep ; Boz, Cavit ; Bergamaschi, Roberto ; Piccolo, Guiseppe ; Oger, Joel ; Swerdlow, Michael L. / Neuromyelitis optica in patients with myasthenia gravis who underwent thymectomy. In: Archives of Neurology. 2006 ; Vol. 63, No. 6. pp. 851-856.
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AU - Piccolo, Guiseppe

AU - Oger, Joel

AU - Swerdlow, Michael L.

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