Neuromyelitis optica spectrum disorder as a paraneoplastic manifestation of lung adenocarcinoma expressing aquaporin-4

Raffaele Iorio, Guido Rindi, Carmen Erra, Valentina Damato, Michela Ferilli, Mario Sabatelli

Research output: Contribution to journalArticle

Abstract

Background: The observations of neuromyelitis optica spectrum disorders (NMOSD) occurring in the setting of cancer suggest that aquaporin-4 (AQP4) autoimmunity may in some cases be paraneoplastic. Results: We describe a 72-year-old patient who developed a longitudinally extensive transverse myelitis associated with AQP4 autoantibodies in the setting of a lung adenocarcinoma recurrence. AQP4 expression was demonstrated in tumor cells. IgG in patients cerebrospinal fluid bound to tumor cells co-localizing with AQP4 immunoreactivity. Conclusions and relevance: This case expands the spectrum of paraneoplastic AQP4 autoimmunity highlighting the importance of considering an oncological screening in patients with late-onset NMOSD.

Original languageEnglish
Pages (from-to)791-794
Number of pages4
JournalMultiple Sclerosis Journal
Volume21
Issue number6
DOIs
Publication statusPublished - May 4 2015

Keywords

  • neuromyelitis optica
  • Paraneoplastic

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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