Long-term changes in neuronal multiunit activity (MUA) in the forepaw region of the somatosensory cortex (S1FL) in conscious rats were studied after transient focal ischemia (Endothelin-1 model of occlusion of the middle cerebral artery, EMCAO). EMCAO produced profound and long-lasting suppression of MUA. The serotonin-2A receptor (5-HT2A) antagonist ketanserin when administered in the acute phase of ischemia recovered the EMCAO-induced suppression of MUA frequency later. These findings indicate that ketanserin is able to make cells in penumbra evolve towards recovery.
|Number of pages||6|
|Journal||Comptes Rendus de L'Academie Bulgare des Sciences|
|Publication status||Published - 2009|
- Endothelin-1 model of focal brain ischemia
- Multiunit activity
ASJC Scopus subject areas