Neuronal activity in cortical ischemic penumbra in conscious rats with stroke and the effect of a 5-HT2A receptor antagonist

Slavianka Moyanova, Roumen Kirov, Lidia Kortenska

Research output: Contribution to journalArticle

Abstract

Long-term changes in neuronal multiunit activity (MUA) in the forepaw region of the somatosensory cortex (S1FL) in conscious rats were studied after transient focal ischemia (Endothelin-1 model of occlusion of the middle cerebral artery, EMCAO). EMCAO produced profound and long-lasting suppression of MUA. The serotonin-2A receptor (5-HT2A) antagonist ketanserin when administered in the acute phase of ischemia recovered the EMCAO-induced suppression of MUA frequency later. These findings indicate that ketanserin is able to make cells in penumbra evolve towards recovery.

Original languageEnglish
Pages (from-to)1417-1422
Number of pages6
JournalComptes Rendus de L'Academie Bulgare des Sciences
Volume62
Issue number11
Publication statusPublished - 2009

Keywords

  • Endothelin-1 model of focal brain ischemia
  • Ketanserin
  • Multiunit activity

ASJC Scopus subject areas

  • General

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