Neuronal caspase-3 signaling: Not only cell death

M. D'Amelio, V. Cavallucci, F. Cecconi

Research output: Contribution to journalArticlepeer-review


Caspases are a family of cysteinyl aspartate-specific proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. A member of this family, caspase-3, has been identified as a key mediator of apoptosis in neuronal cells. Recent studies in snail, fly and rat suggest that caspase-3 also functions as a regulatory molecule in neurogenesis and synaptic activity. In this study, in addition to providing an overview of the mechanism of caspase-3 activation, we review genetic and pharmacological studies of apoptotic and nonapoptotic functions of caspase-3 and discuss the regulatory mechanism of caspase-3 for executing nonapoptotic functions in the central nervous system. Knowledge of biochemical pathway(s) for nonapoptotic activation and modulation of caspase-3 has potential implications for the understanding of synaptic failure in the pathophysiology of neurological disorders. Fine-tuning of caspase-3 lays down a new challenge in identifying pharmacological avenues for treatment of many neurological disorders.

Original languageEnglish
Pages (from-to)1104-1114
Number of pages11
JournalCell Death and Differentiation
Issue number7
Publication statusPublished - Jul 2010


  • Apoptosis
  • Neurodegeneration
  • Neurodevelopment
  • Neuron differentiation
  • Synaptic plasticity

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)


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