Dominant megacolon (Dom) is one of four mutations in the mouse which can produce a phenotype similar to Hirschsprung disease in man. Here, we report that it is possible to take advantage of two microsatellite markers to genotype Dom embryos and to study enteric neuronal development in Dom embryos using whole-mount immunohistochemistry. Do embryos present a variable defect in the ileo-caecal region, as do embryos of other murine models of Hirschsprung disease.
|Number of pages||4|
|Publication status||Published - 1996|
- enteric neural system development
- Hirschsprung disease
- neural crest
ASJC Scopus subject areas