Neuronal defects in genotyped dominant megacolon (Dom) mouse embryos, a model for Hirschsprung disease

Aldamaria Puliti, Véronique Poirier, Michel Goossens, Michel Simonneau

Research output: Contribution to journalArticle


Dominant megacolon (Dom) is one of four mutations in the mouse which can produce a phenotype similar to Hirschsprung disease in man. Here, we report that it is possible to take advantage of two microsatellite markers to genotype Dom embryos and to study enteric neuronal development in Dom embryos using whole-mount immunohistochemistry. Do embryos present a variable defect in the ileo-caecal region, as do embryos of other murine models of Hirschsprung disease.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
Issue number2
Publication statusPublished - 1996



  • enteric neural system development
  • Hirschsprung disease
  • megacolon
  • neural crest

ASJC Scopus subject areas

  • Neuroscience(all)

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