Neuronal functionality assessed by magnetoencephalography is related to oxidative stress system in acute ischemic stroke

Giovanni Assenza, Filippo Zappasodi, Rosanna Squitti, Claudia Altamura, Mariacarla Ventriglia, Matilde Ercolani, Carlo Cosimo Quattrocchi, Domenico Lupoi, Francesco Passarelli, Fabrizio Vernieri, Paolo Maria Rossini, Franca Tecchio

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Abstract

The hypoxic brain damage induced by stroke is followed by an ischemia-reperfusion injury modulated by oxidative stress. Magnetoencephalographic (MEG) recording of rest and evoked cortical activities is a sensitive method to analyse functional changes following the acute ischemic damage. We aimed at investigating whether MEG signals are related to oxidative stress compounds in acute stroke. Eighteen stroke patients and 20 controls were enrolled. All subjects underwent MEG assessment to record background activity and somatosensory evoked responses (M20 and M30) of rolandic regions, neurological examination assessed by National Institute of Health Stroke Scale (NIHSS) and plasmatic measurement of copper, iron, zinc, ceruloplasmin, transferrin, total peroxides and Total Anti-Oxidant Status. Magnetic Resonance was performed to estimate the lesion site and volume. Delta power and M20 equivalent current dipole (ECD) strength in the affected hemisphere (AH) correlated with NIHSS scores (respectively, rho = .692, p = .006 and rho = - .627, p = .012) and taken together explained 67% of NIHSS variability (p = .004). Higher transferrin and lower peroxides levels correlated with better clinical status (respectively, rho = - .600, p = .014 and rho = .599, p = .011). Transferrin also correlated with AH M20 ECD strength (rho = .638 p = .014) and inversely with AH delta power (rho = - .646 p = .023) and the lesion volume, especially in cortico-subcortical stroke (p = .037). Our findings strengthen MEG reliability in honing the evaluation of neuronal damage in acute ischemic stroke also demonstrating an association between the MEG parameters most representing the clinical status and the oxidative stress compounds. Our results meet at a possible protective role of transferrin in limiting the oxidative damage in acute stroke.

Original languageEnglish
Pages (from-to)1267-1273
Number of pages7
JournalNeuroImage
Volume44
Issue number4
DOIs
Publication statusPublished - Feb 15 2009

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Magnetoencephalography
Oxidative Stress
Stroke
Transferrin
National Institutes of Health (U.S.)
Peroxides
Brain Hypoxia
Ceruloplasmin
Neurologic Examination
Reperfusion Injury
Oxidants
Zinc
Copper
Magnetic Resonance Spectroscopy
Iron

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Assenza, G., Zappasodi, F., Squitti, R., Altamura, C., Ventriglia, M., Ercolani, M., ... Tecchio, F. (2009). Neuronal functionality assessed by magnetoencephalography is related to oxidative stress system in acute ischemic stroke. NeuroImage, 44(4), 1267-1273. https://doi.org/10.1016/j.neuroimage.2008.09.049

Neuronal functionality assessed by magnetoencephalography is related to oxidative stress system in acute ischemic stroke. / Assenza, Giovanni; Zappasodi, Filippo; Squitti, Rosanna; Altamura, Claudia; Ventriglia, Mariacarla; Ercolani, Matilde; Quattrocchi, Carlo Cosimo; Lupoi, Domenico; Passarelli, Francesco; Vernieri, Fabrizio; Rossini, Paolo Maria; Tecchio, Franca.

In: NeuroImage, Vol. 44, No. 4, 15.02.2009, p. 1267-1273.

Research output: Contribution to journalArticle

Assenza, G, Zappasodi, F, Squitti, R, Altamura, C, Ventriglia, M, Ercolani, M, Quattrocchi, CC, Lupoi, D, Passarelli, F, Vernieri, F, Rossini, PM & Tecchio, F 2009, 'Neuronal functionality assessed by magnetoencephalography is related to oxidative stress system in acute ischemic stroke', NeuroImage, vol. 44, no. 4, pp. 1267-1273. https://doi.org/10.1016/j.neuroimage.2008.09.049
Assenza, Giovanni ; Zappasodi, Filippo ; Squitti, Rosanna ; Altamura, Claudia ; Ventriglia, Mariacarla ; Ercolani, Matilde ; Quattrocchi, Carlo Cosimo ; Lupoi, Domenico ; Passarelli, Francesco ; Vernieri, Fabrizio ; Rossini, Paolo Maria ; Tecchio, Franca. / Neuronal functionality assessed by magnetoencephalography is related to oxidative stress system in acute ischemic stroke. In: NeuroImage. 2009 ; Vol. 44, No. 4. pp. 1267-1273.
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