Neuronal localization of benzodiazepine receptors in the murine cerebellum.

R. C. Speth, N. Bresolin, T. Mimaki, P. P. Deshmukh, H. I. Yamamura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Selective genetic and chemical lesions which affect specific neuronal populations in the cerebellum were studied for changes in benzodiazepine receptors. Destruction of cerebellar climbing fibers with 3-acetylpyridine, did not affect cerebellar benzodiazepine receptors. Destruction of Purkinje, basket and stellate cells with intracerebellar kainic acid, caused moderate decreases in benzodiazepine receptor density. Destruction of Purkinje cells with chronic high doses of phenytoin also caused a significant decrease in benzodiazepine receptor density. In "weaver" mice, which have a severe loss of granule cells, benzodiazepine receptor density was unchanged, while the absolute number of benzodiazepine receptors decreased by 57%. In "staggerer" mice which have diminished Purkinje cells dendritic thickenings at their synapses with parallel fibers and subsequent granule cell loss, there was a 45% decrease in benzodiazepine receptor density and a 90% decrease in the absolute number of benzodiazepine receptors. These results suggest that benzodiazepine receptors exist on cerebellar Purkinje cells, that they probably also occur on cerebellar granule cells, and that they do not appear to be present on cerebellar glial cells or on climbing fibers.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalAdvances in biochemical psychopharmacology
Volume26
Publication statusPublished - 1981

Fingerprint

GABA-A Receptors
Cerebellum
Purkinje Cells
Neurologic Mutant Mice
Kainic Acid
Phenytoin
Neuroglia
Synapses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuronal localization of benzodiazepine receptors in the murine cerebellum. / Speth, R. C.; Bresolin, N.; Mimaki, T.; Deshmukh, P. P.; Yamamura, H. I.

In: Advances in biochemical psychopharmacology, Vol. 26, 1981, p. 27-39.

Research output: Contribution to journalArticle

Speth, R. C. ; Bresolin, N. ; Mimaki, T. ; Deshmukh, P. P. ; Yamamura, H. I. / Neuronal localization of benzodiazepine receptors in the murine cerebellum. In: Advances in biochemical psychopharmacology. 1981 ; Vol. 26. pp. 27-39.
@article{a8649b1c65c94d96ac558f2a12734c64,
title = "Neuronal localization of benzodiazepine receptors in the murine cerebellum.",
abstract = "Selective genetic and chemical lesions which affect specific neuronal populations in the cerebellum were studied for changes in benzodiazepine receptors. Destruction of cerebellar climbing fibers with 3-acetylpyridine, did not affect cerebellar benzodiazepine receptors. Destruction of Purkinje, basket and stellate cells with intracerebellar kainic acid, caused moderate decreases in benzodiazepine receptor density. Destruction of Purkinje cells with chronic high doses of phenytoin also caused a significant decrease in benzodiazepine receptor density. In {"}weaver{"} mice, which have a severe loss of granule cells, benzodiazepine receptor density was unchanged, while the absolute number of benzodiazepine receptors decreased by 57{\%}. In {"}staggerer{"} mice which have diminished Purkinje cells dendritic thickenings at their synapses with parallel fibers and subsequent granule cell loss, there was a 45{\%} decrease in benzodiazepine receptor density and a 90{\%} decrease in the absolute number of benzodiazepine receptors. These results suggest that benzodiazepine receptors exist on cerebellar Purkinje cells, that they probably also occur on cerebellar granule cells, and that they do not appear to be present on cerebellar glial cells or on climbing fibers.",
author = "Speth, {R. C.} and N. Bresolin and T. Mimaki and Deshmukh, {P. P.} and Yamamura, {H. I.}",
year = "1981",
language = "English",
volume = "26",
pages = "27--39",
journal = "Advances in biochemical psychopharmacology",
issn = "0065-2229",

}

TY - JOUR

T1 - Neuronal localization of benzodiazepine receptors in the murine cerebellum.

AU - Speth, R. C.

AU - Bresolin, N.

AU - Mimaki, T.

AU - Deshmukh, P. P.

AU - Yamamura, H. I.

PY - 1981

Y1 - 1981

N2 - Selective genetic and chemical lesions which affect specific neuronal populations in the cerebellum were studied for changes in benzodiazepine receptors. Destruction of cerebellar climbing fibers with 3-acetylpyridine, did not affect cerebellar benzodiazepine receptors. Destruction of Purkinje, basket and stellate cells with intracerebellar kainic acid, caused moderate decreases in benzodiazepine receptor density. Destruction of Purkinje cells with chronic high doses of phenytoin also caused a significant decrease in benzodiazepine receptor density. In "weaver" mice, which have a severe loss of granule cells, benzodiazepine receptor density was unchanged, while the absolute number of benzodiazepine receptors decreased by 57%. In "staggerer" mice which have diminished Purkinje cells dendritic thickenings at their synapses with parallel fibers and subsequent granule cell loss, there was a 45% decrease in benzodiazepine receptor density and a 90% decrease in the absolute number of benzodiazepine receptors. These results suggest that benzodiazepine receptors exist on cerebellar Purkinje cells, that they probably also occur on cerebellar granule cells, and that they do not appear to be present on cerebellar glial cells or on climbing fibers.

AB - Selective genetic and chemical lesions which affect specific neuronal populations in the cerebellum were studied for changes in benzodiazepine receptors. Destruction of cerebellar climbing fibers with 3-acetylpyridine, did not affect cerebellar benzodiazepine receptors. Destruction of Purkinje, basket and stellate cells with intracerebellar kainic acid, caused moderate decreases in benzodiazepine receptor density. Destruction of Purkinje cells with chronic high doses of phenytoin also caused a significant decrease in benzodiazepine receptor density. In "weaver" mice, which have a severe loss of granule cells, benzodiazepine receptor density was unchanged, while the absolute number of benzodiazepine receptors decreased by 57%. In "staggerer" mice which have diminished Purkinje cells dendritic thickenings at their synapses with parallel fibers and subsequent granule cell loss, there was a 45% decrease in benzodiazepine receptor density and a 90% decrease in the absolute number of benzodiazepine receptors. These results suggest that benzodiazepine receptors exist on cerebellar Purkinje cells, that they probably also occur on cerebellar granule cells, and that they do not appear to be present on cerebellar glial cells or on climbing fibers.

UR - http://www.scopus.com/inward/record.url?scp=0019399074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019399074&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 27

EP - 39

JO - Advances in biochemical psychopharmacology

JF - Advances in biochemical psychopharmacology

SN - 0065-2229

ER -