Abstract
Selective genetic and chemical lesions which affect specific neuronal populations in the cerebellum were studied for changes in benzodiazepine receptors. Destruction of cerebellar climbing fibers with 3-acetylpyridine, did not affect cerebellar benzodiazepine receptors. Destruction of Purkinje, basket and stellate cells with intracerebellar kainic acid, caused moderate decreases in benzodiazepine receptor density. Destruction of Purkinje cells with chronic high doses of phenytoin also caused a significant decrease in benzodiazepine receptor density. In "weaver" mice, which have a severe loss of granule cells, benzodiazepine receptor density was unchanged, while the absolute number of benzodiazepine receptors decreased by 57%. In "staggerer" mice which have diminished Purkinje cells dendritic thickenings at their synapses with parallel fibers and subsequent granule cell loss, there was a 45% decrease in benzodiazepine receptor density and a 90% decrease in the absolute number of benzodiazepine receptors. These results suggest that benzodiazepine receptors exist on cerebellar Purkinje cells, that they probably also occur on cerebellar granule cells, and that they do not appear to be present on cerebellar glial cells or on climbing fibers.
| Original language | English |
|---|---|
| Pages (from-to) | 27-39 |
| Number of pages | 13 |
| Journal | Advances in biochemical psychopharmacology |
| Volume | 26 |
| Publication status | Published - 1981 |
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Neuronal localization of benzodiazepine receptors in the murine cerebellum. / Speth, R. C.; Bresolin, N.; Mimaki, T.; Deshmukh, P. P.; Yamamura, H. I.
In: Advances in biochemical psychopharmacology, Vol. 26, 1981, p. 27-39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuronal localization of benzodiazepine receptors in the murine cerebellum.
AU - Speth, R. C.
AU - Bresolin, N.
AU - Mimaki, T.
AU - Deshmukh, P. P.
AU - Yamamura, H. I.
PY - 1981
Y1 - 1981
N2 - Selective genetic and chemical lesions which affect specific neuronal populations in the cerebellum were studied for changes in benzodiazepine receptors. Destruction of cerebellar climbing fibers with 3-acetylpyridine, did not affect cerebellar benzodiazepine receptors. Destruction of Purkinje, basket and stellate cells with intracerebellar kainic acid, caused moderate decreases in benzodiazepine receptor density. Destruction of Purkinje cells with chronic high doses of phenytoin also caused a significant decrease in benzodiazepine receptor density. In "weaver" mice, which have a severe loss of granule cells, benzodiazepine receptor density was unchanged, while the absolute number of benzodiazepine receptors decreased by 57%. In "staggerer" mice which have diminished Purkinje cells dendritic thickenings at their synapses with parallel fibers and subsequent granule cell loss, there was a 45% decrease in benzodiazepine receptor density and a 90% decrease in the absolute number of benzodiazepine receptors. These results suggest that benzodiazepine receptors exist on cerebellar Purkinje cells, that they probably also occur on cerebellar granule cells, and that they do not appear to be present on cerebellar glial cells or on climbing fibers.
AB - Selective genetic and chemical lesions which affect specific neuronal populations in the cerebellum were studied for changes in benzodiazepine receptors. Destruction of cerebellar climbing fibers with 3-acetylpyridine, did not affect cerebellar benzodiazepine receptors. Destruction of Purkinje, basket and stellate cells with intracerebellar kainic acid, caused moderate decreases in benzodiazepine receptor density. Destruction of Purkinje cells with chronic high doses of phenytoin also caused a significant decrease in benzodiazepine receptor density. In "weaver" mice, which have a severe loss of granule cells, benzodiazepine receptor density was unchanged, while the absolute number of benzodiazepine receptors decreased by 57%. In "staggerer" mice which have diminished Purkinje cells dendritic thickenings at their synapses with parallel fibers and subsequent granule cell loss, there was a 45% decrease in benzodiazepine receptor density and a 90% decrease in the absolute number of benzodiazepine receptors. These results suggest that benzodiazepine receptors exist on cerebellar Purkinje cells, that they probably also occur on cerebellar granule cells, and that they do not appear to be present on cerebellar glial cells or on climbing fibers.
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M3 - Article
VL - 26
SP - 27
EP - 39
JO - Advances in biochemical psychopharmacology
JF - Advances in biochemical psychopharmacology
SN - 0065-2229
ER -