Neuronal loss in the basal nucleus of meynert in progressive supranuclear palsy

F. Tagliavini, G. Pilleri, F. Gemignani, A. Lechi

Research output: Contribution to journalArticlepeer-review


A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric methods in PSP, but the involvement of the bnM is well known in other related conditions, i.e., Parkinson's disease. Alzheimer's disease, and Parkinson-dementia complex of Guam. Our findings yield support to the view that the involvement of the bnM, a nucleus with complex connections with various subcortical structures and diffuse cholinergic projections on the neocortex, could play an important role in the physiopathogeny of subcortical dementia.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalActa Neuropathologica
Issue number2
Publication statusPublished - Jun 1983


  • Basal nucleus of Meynert
  • Neuropathology
  • Progressive supranuclear palsy (PSP)
  • Subcortical dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology


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