Neuronal mechanisms regulating ethanol effects on the dopaminergic system

M. L. Barbaccia; A. Bosio; L. Lucchi; P. F. Spano; M. Trabucchi

doi:10.1016/0024-3205(82)90290-9

Neuronal mechanisms regulating ethanol effects on the dopaminergic system

M. L. Barbaccia, A. Bosio, L. Lucchi, P. F. Spano, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

Chronic ethanol consumption induces an increase in striatal ³H-Spiroperidol and ³H(-) Sulpiride specific binding by enhancing the affinity between the different dopaminergic recognition sites and the labelled ligands. Dopamine (DA) receptor supersensitivity is also suggested by the enhanced effect of neuroleptics in inducing hypomotility in rats treated with ethanol. The results, obtained by means of the administration of neuroleptics in comparison to ethanol treated rats, indicate a lack of cross tolerance between ethanol and other drugs acting on the dopaminergic recognition sites. These data suggest that ethanol effects on the dopaminergic system are mediated by events involving other neurotransmitter systems.

Original language	English
Pages (from-to)	2163-2170
Number of pages	8
Journal	Life Sciences
Volume	30
Issue number	25
DOIs	https://doi.org/10.1016/0024-3205(82)90290-9
Publication status	Published - Jun 21 1982

Fingerprint

Ethanol

Antipsychotic Agents

Rats

Corpus Striatum

Spiperone

Sulpiride

Dopamine Receptors

Neurotransmitter Agents

Ligands

Pharmaceutical Preparations

ASJC Scopus subject areas

Pharmacology

Cite this

Barbaccia, M. L., Bosio, A., Lucchi, L., Spano, P. F., & Trabucchi, M. (1982). Neuronal mechanisms regulating ethanol effects on the dopaminergic system. Life Sciences, 30(25), 2163-2170. https://doi.org/10.1016/0024-3205(82)90290-9

Neuronal mechanisms regulating ethanol effects on the dopaminergic system. / Barbaccia, M. L.; Bosio, A.; Lucchi, L.; Spano, P. F.; Trabucchi, M.

In: Life Sciences, Vol. 30, No. 25, 21.06.1982, p. 2163-2170.

Research output: Contribution to journal › Article

Barbaccia, ML, Bosio, A, Lucchi, L, Spano, PF & Trabucchi, M 1982, 'Neuronal mechanisms regulating ethanol effects on the dopaminergic system', Life Sciences, vol. 30, no. 25, pp. 2163-2170. https://doi.org/10.1016/0024-3205(82)90290-9

Barbaccia ML, Bosio A, Lucchi L, Spano PF, Trabucchi M. Neuronal mechanisms regulating ethanol effects on the dopaminergic system. Life Sciences. 1982 Jun 21;30(25):2163-2170. https://doi.org/10.1016/0024-3205(82)90290-9

Barbaccia, M. L. ; Bosio, A. ; Lucchi, L. ; Spano, P. F. ; Trabucchi, M. / Neuronal mechanisms regulating ethanol effects on the dopaminergic system. In: Life Sciences. 1982 ; Vol. 30, No. 25. pp. 2163-2170.

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10.1016/0024-3205(82)90290-9