Neuronal mechanisms regulating ethanol effects on the dopaminergic system

M. L. Barbaccia; A. Bosio; L. Lucchi; P. F. Spano; M. Trabucchi

doi:10.1016/0024-3205(82)90290-9

Neuronal mechanisms regulating ethanol effects on the dopaminergic system

M. L. Barbaccia, A. Bosio, L. Lucchi, P. F. Spano, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic ethanol consumption induces an increase in striatal ³H-Spiroperidol and ³H(-) Sulpiride specific binding by enhancing the affinity between the different dopaminergic recognition sites and the labelled ligands. Dopamine (DA) receptor supersensitivity is also suggested by the enhanced effect of neuroleptics in inducing hypomotility in rats treated with ethanol. The results, obtained by means of the administration of neuroleptics in comparison to ethanol treated rats, indicate a lack of cross tolerance between ethanol and other drugs acting on the dopaminergic recognition sites. These data suggest that ethanol effects on the dopaminergic system are mediated by events involving other neurotransmitter systems.

Original language	English
Pages (from-to)	2163-2170
Number of pages	8
Journal	Life Sciences
Volume	30
Issue number	25
DOIs	https://doi.org/10.1016/0024-3205(82)90290-9
Publication status	Published - Jun 21 1982

ASJC Scopus subject areas

Pharmacology

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10.1016/0024-3205(82)90290-9

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title = "Neuronal mechanisms regulating ethanol effects on the dopaminergic system",

abstract = "Chronic ethanol consumption induces an increase in striatal 3H-Spiroperidol and 3H(-) Sulpiride specific binding by enhancing the affinity between the different dopaminergic recognition sites and the labelled ligands. Dopamine (DA) receptor supersensitivity is also suggested by the enhanced effect of neuroleptics in inducing hypomotility in rats treated with ethanol. The results, obtained by means of the administration of neuroleptics in comparison to ethanol treated rats, indicate a lack of cross tolerance between ethanol and other drugs acting on the dopaminergic recognition sites. These data suggest that ethanol effects on the dopaminergic system are mediated by events involving other neurotransmitter systems.",

author = "Barbaccia, {M. L.} and A. Bosio and L. Lucchi and Spano, {P. F.} and M. Trabucchi",

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AU - Barbaccia, M. L.

AU - Bosio, A.

AU - Lucchi, L.

AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1982/6/21

Y1 - 1982/6/21

N2 - Chronic ethanol consumption induces an increase in striatal 3H-Spiroperidol and 3H(-) Sulpiride specific binding by enhancing the affinity between the different dopaminergic recognition sites and the labelled ligands. Dopamine (DA) receptor supersensitivity is also suggested by the enhanced effect of neuroleptics in inducing hypomotility in rats treated with ethanol. The results, obtained by means of the administration of neuroleptics in comparison to ethanol treated rats, indicate a lack of cross tolerance between ethanol and other drugs acting on the dopaminergic recognition sites. These data suggest that ethanol effects on the dopaminergic system are mediated by events involving other neurotransmitter systems.

AB - Chronic ethanol consumption induces an increase in striatal 3H-Spiroperidol and 3H(-) Sulpiride specific binding by enhancing the affinity between the different dopaminergic recognition sites and the labelled ligands. Dopamine (DA) receptor supersensitivity is also suggested by the enhanced effect of neuroleptics in inducing hypomotility in rats treated with ethanol. The results, obtained by means of the administration of neuroleptics in comparison to ethanol treated rats, indicate a lack of cross tolerance between ethanol and other drugs acting on the dopaminergic recognition sites. These data suggest that ethanol effects on the dopaminergic system are mediated by events involving other neurotransmitter systems.

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Neuronal mechanisms regulating ethanol effects on the dopaminergic system

Abstract

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