Neuronal mechanisms regulating ethanol effects on the dopaminergic system

M. L. Barbaccia, A. Bosio, L. Lucchi, P. F. Spano, M. Trabucchi

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Abstract

Chronic ethanol consumption induces an increase in striatal 3H-Spiroperidol and 3H(-) Sulpiride specific binding by enhancing the affinity between the different dopaminergic recognition sites and the labelled ligands. Dopamine (DA) receptor supersensitivity is also suggested by the enhanced effect of neuroleptics in inducing hypomotility in rats treated with ethanol. The results, obtained by means of the administration of neuroleptics in comparison to ethanol treated rats, indicate a lack of cross tolerance between ethanol and other drugs acting on the dopaminergic recognition sites. These data suggest that ethanol effects on the dopaminergic system are mediated by events involving other neurotransmitter systems.

Original languageEnglish
Pages (from-to)2163-2170
Number of pages8
JournalLife Sciences
Volume30
Issue number25
DOIs
Publication statusPublished - Jun 21 1982

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Barbaccia, M. L., Bosio, A., Lucchi, L., Spano, P. F., & Trabucchi, M. (1982). Neuronal mechanisms regulating ethanol effects on the dopaminergic system. Life Sciences, 30(25), 2163-2170. https://doi.org/10.1016/0024-3205(82)90290-9