Electroclinical data from 28 cases with neuronal migration disorders (NMD) are reported. All cases were diagnosed by CT scan and/or MR, and subdivided in 5 groups acoording to the type and extent of NMD. Epilepsy was present in 24 out of 28 cases, with onset in the first or second decade of life. Only 3 cases with diffuse and bilateral gray matter heterotopias presented as early epileptic encephalopathy. Seizure were of focal type in most cases, often resistant to rational antiepileptic treatment. There was always a good correlation between the location of NMD, interictal epileptiform activity at the EEGs, and ictal semiology. In the group with NMD associated to agenesis of corpus callosum epilepsy was interestingly present only in 3 out of 6 cases, with sporadic focal seizures well responsive to antiepileptic treatment.
|Translated title of the contribution||Neuronal migration disorders and epilepsy. A survey of adult and infantile cases observed at Neurological Institute 'C. Besta' of Milan|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Neurology