Neuronal networks in the in vitro isolated guinea pig brain

Marco De Curtis, Laura Librizzi, Laura Uva, Vadym Gnatkovsky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neuronal networks can be properly analyzed in experimental preparations that preserve the largest -connectivity within and between brain structures. The isolated whole guinea pig brain maintained in vitro by arterial perfusion is ideal for this purpose. The methods and techniques utilized to study brain networks in this preparation are reviewed in this chapter. The advantages, potentials, and limitations for the study of pathological activity in models of acute (and chronic) cerebral diseases, such as epilepsy and ischemia, are also discussed.

Original languageEnglish
Title of host publicationNeuromethods
Pages357-383
Number of pages27
Volume73
DOIs
Publication statusPublished - 2012

Publication series

NameNeuromethods
Volume73
ISSN (Print)08932336
ISSN (Electronic)19406045

Keywords

  • Blood-brain barrier
  • Cerebral ischemia
  • Epilepsy
  • In vitro
  • Isolated guinea pig brain
  • Limbic system
  • Olfactory cortex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Psychiatry and Mental health

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