Neuronal semaphorins regulate a primary immune response

Simona Moretti, Antonio Procopio, Massimo Boemi, Alfonso Catalano

Research output: Contribution to journalArticlepeer-review


Semaphorins are involved in a wide range of biological processes, including axon guidance, neuronal migration, angiogenesis, cardio- and osteo-genesis. Recently they have also been found to be important for immune response. Sema3A reduces the activation of T cells through its cell-surface receptors, including members of the neuropilin and plexin families. By contrast, Sema4D (CD100), which is expressed on the surface of T, B and dendritic cells, increases B cell and dendritic cell function using either plexin B1 or CD72 as receptors. The transmembrane protein Sema4A is involved in the activation of immune cells through interactions with Tim-2. Emerging evidence also indicates that additional semaphorins and related molecules seem to function in the reciprocal stimulation of T cells and antigen-presenting cells (APCs). This paper discusses the functions of these semaphorins in the immune system, focusing on their roles in T cell-APC interactions.

Original languageEnglish
Pages (from-to)295-305
Number of pages11
JournalCurrent Neurovascular Research
Issue number4
Publication statusPublished - Nov 2006


  • Immune semaphorins
  • Immune system
  • Nervous system
  • Sema-3A
  • Sema-4A
  • Sema-4D
  • Semaphorin pathways

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Neuronal semaphorins regulate a primary immune response'. Together they form a unique fingerprint.

Cite this