Neurons dissociated from neocortex fire with 'burst' and 'regular' trains of spikes

E. Guatteo, A. Bacci, S. Franceschetti, G. Avanzini, E. Wanke

Research output: Contribution to journalArticlepeer-review


Neurons acutely dissociated from neocortex slices of 14-16-day-old rats were patch-clamped in physiological conditions. Different pyramidal cells, spontaneously or in response to current steps, generate regular spiking and intrinsically bursting behaviour during long periods of time. We show that typical firing properties recorded in somatosensory neocortex slices are preserved in dissociated pyramidal neurons originating from the slices themselves, thus, providing a way for the related characterization of biophysical properties of currents in identified subtypes of pyramidal neurons.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - Jul 4 1994


  • Bursting
  • Dissociated neuron
  • Firing characteristics
  • Neocortex

ASJC Scopus subject areas

  • Neuroscience(all)


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