Neuropeptide α-MSH antagonizes IL-6- and TNF-induced fever

L. W. Martin; A. Catania; M. E. Hiltz; J. M. Lipton

doi:10.1016/0196-9781(91)90015-H

Neuropeptide α-MSH antagonizes IL-6- and TNF-induced fever

L. W. Martin, A. Catania, M. E. Hiltz, J. M. Lipton

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The pro-opiomelanocortin-derived peptide melanocyte stimulating hormone (α-MSH) antagonizes the fever induced by several stimuli including endotoxin, endogenous pyrogen, and certain cytokines. To determine if α-MSH can antagonize the pyrogenic action of recombinant IL-6 and TNF directly within the central nervous system, the cytokines were injected with and without α-MSH (200 ng) into a lateral cerebral ventricle of rabbits and rectal temperature was monitored continuously. Central administration of both cytokines caused fever. However, when α-MSH was injected after cytokine administration, the fevers were markedly reduced. The results are consistent with previous observations on the antipyretic effect of α-MSH and they show that the peptide can act within the brain to antagonize pyrogenic actions of specific cytokines believed to be important in CNS mediation of fever.

Original language	English
Pages (from-to)	297-299
Number of pages	3
Journal	Peptides
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(91)90015-H
Publication status	Published - 1991

Keywords

Cytokines
Fever
Interleukin-6
Tumor necrosis factor-α
α-Melanocyte stimulating hormone

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0196-9781(91)90015-H

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title = "Neuropeptide α-MSH antagonizes IL-6- and TNF-induced fever",

abstract = "The pro-opiomelanocortin-derived peptide melanocyte stimulating hormone (α-MSH) antagonizes the fever induced by several stimuli including endotoxin, endogenous pyrogen, and certain cytokines. To determine if α-MSH can antagonize the pyrogenic action of recombinant IL-6 and TNF directly within the central nervous system, the cytokines were injected with and without α-MSH (200 ng) into a lateral cerebral ventricle of rabbits and rectal temperature was monitored continuously. Central administration of both cytokines caused fever. However, when α-MSH was injected after cytokine administration, the fevers were markedly reduced. The results are consistent with previous observations on the antipyretic effect of α-MSH and they show that the peptide can act within the brain to antagonize pyrogenic actions of specific cytokines believed to be important in CNS mediation of fever.",

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AU - Martin, L. W.

AU - Catania, A.

AU - Hiltz, M. E.

AU - Lipton, J. M.

PY - 1991

Y1 - 1991

N2 - The pro-opiomelanocortin-derived peptide melanocyte stimulating hormone (α-MSH) antagonizes the fever induced by several stimuli including endotoxin, endogenous pyrogen, and certain cytokines. To determine if α-MSH can antagonize the pyrogenic action of recombinant IL-6 and TNF directly within the central nervous system, the cytokines were injected with and without α-MSH (200 ng) into a lateral cerebral ventricle of rabbits and rectal temperature was monitored continuously. Central administration of both cytokines caused fever. However, when α-MSH was injected after cytokine administration, the fevers were markedly reduced. The results are consistent with previous observations on the antipyretic effect of α-MSH and they show that the peptide can act within the brain to antagonize pyrogenic actions of specific cytokines believed to be important in CNS mediation of fever.

AB - The pro-opiomelanocortin-derived peptide melanocyte stimulating hormone (α-MSH) antagonizes the fever induced by several stimuli including endotoxin, endogenous pyrogen, and certain cytokines. To determine if α-MSH can antagonize the pyrogenic action of recombinant IL-6 and TNF directly within the central nervous system, the cytokines were injected with and without α-MSH (200 ng) into a lateral cerebral ventricle of rabbits and rectal temperature was monitored continuously. Central administration of both cytokines caused fever. However, when α-MSH was injected after cytokine administration, the fevers were markedly reduced. The results are consistent with previous observations on the antipyretic effect of α-MSH and they show that the peptide can act within the brain to antagonize pyrogenic actions of specific cytokines believed to be important in CNS mediation of fever.

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