Neuropeptide Y: Emerging evidence for a functional role in seizure modulation

Annamaria Vezzani, Günther Sperk, William F. Colmers

Research output: Contribution to journalArticle

382 Citations (Scopus)

Abstract

The high concentration of the tyrosine-rich polypeptide, neuropeptide Y (NPY), and the increase in the number of its receptor subtypes that have been characterized in the brain, raise the question of a functional role for NPY in the CNS. In addition to its peripheral actions on cardiovascular regulation, much attention has, therefore, been devoted to the CNS effects of NPY because of its stimulatory properties on food intake, its role in anxiolysis and its putative involvement in memory retention. Emerging evidence points to an important role for NPY in the regulation of neuronal activity both under physiological conditions and during pathological hyperactivity such as that which occurs during seizures. This article reviews recent studies that have shown the changes induced by seizures in the level and distribution of NPY, its receptor subtypes and their respective mRNAs in rat forebrain. Biochemical and electrophysiological findings in experimental models and tissue from human epilepsy sufferers suggest that NPY-mediated neurotransmission is altered by seizures. The pharmacological evidence and functional studies in NPY knockout mice highlight a crucial role for endogenous NPY, acting on different NPY receptors, in the control of seizures.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalTrends in Neurosciences
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 1999

Fingerprint

Neuropeptide Y
Seizures
Neuropeptide Y Receptors
Prosencephalon
Knockout Mice
Synaptic Transmission
Tyrosine
Epilepsy
Theoretical Models
Eating
Pharmacology
Messenger RNA
Peptides
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuropeptide Y : Emerging evidence for a functional role in seizure modulation. / Vezzani, Annamaria; Sperk, Günther; Colmers, William F.

In: Trends in Neurosciences, Vol. 22, No. 1, 01.01.1999, p. 25-30.

Research output: Contribution to journalArticle

Vezzani, Annamaria ; Sperk, Günther ; Colmers, William F. / Neuropeptide Y : Emerging evidence for a functional role in seizure modulation. In: Trends in Neurosciences. 1999 ; Vol. 22, No. 1. pp. 25-30.
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