Neuropeptides and their receptors in the immune system

P. Martin Van Hagen, Leo J. Hofland, A. M C Ten Bokum, E. G R Lichtenauer-Kaligis, Dik J. Kwekkeboom, Diego Ferone, S. W J Lamberts

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are involved in both systems. In this review we discuss the role of two of these neuropeptides, somatostatin and substance P, with regard to their receptor expression in the human immune system and their role in the diagnosis and treatment of immune-mediated diseases.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalAnnals of Medicine
Volume31
Issue numberSUPPL. 2
Publication statusPublished - Oct 1999

Fingerprint

Neuropeptide Receptors
Neuropeptides
Immune System
Immune System Diseases
Substance P
Somatostatin
Neurotransmitter Agents

Keywords

  • Immune system
  • Somatostatin
  • Substance P

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Van Hagen, P. M., Hofland, L. J., Ten Bokum, A. M. C., Lichtenauer-Kaligis, E. G. R., Kwekkeboom, D. J., Ferone, D., & Lamberts, S. W. J. (1999). Neuropeptides and their receptors in the immune system. Annals of Medicine, 31(SUPPL. 2), 15-22.

Neuropeptides and their receptors in the immune system. / Van Hagen, P. Martin; Hofland, Leo J.; Ten Bokum, A. M C; Lichtenauer-Kaligis, E. G R; Kwekkeboom, Dik J.; Ferone, Diego; Lamberts, S. W J.

In: Annals of Medicine, Vol. 31, No. SUPPL. 2, 10.1999, p. 15-22.

Research output: Contribution to journalArticle

Van Hagen, PM, Hofland, LJ, Ten Bokum, AMC, Lichtenauer-Kaligis, EGR, Kwekkeboom, DJ, Ferone, D & Lamberts, SWJ 1999, 'Neuropeptides and their receptors in the immune system', Annals of Medicine, vol. 31, no. SUPPL. 2, pp. 15-22.
Van Hagen PM, Hofland LJ, Ten Bokum AMC, Lichtenauer-Kaligis EGR, Kwekkeboom DJ, Ferone D et al. Neuropeptides and their receptors in the immune system. Annals of Medicine. 1999 Oct;31(SUPPL. 2):15-22.
Van Hagen, P. Martin ; Hofland, Leo J. ; Ten Bokum, A. M C ; Lichtenauer-Kaligis, E. G R ; Kwekkeboom, Dik J. ; Ferone, Diego ; Lamberts, S. W J. / Neuropeptides and their receptors in the immune system. In: Annals of Medicine. 1999 ; Vol. 31, No. SUPPL. 2. pp. 15-22.
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