Abstract
PURPOSE: Myotonic dystrophy type 1 is the most common muscular dystrophy in adults. Although brain involvement is well recognized, the relationship between cortical motor control and voluntary movement has not been sufficiently explored. This study aims at assessing magnetoencephalographic (MEG) rhythms at oscillatory and connectivity levels to map central motor control. METHODS: Magnetoencephalographic data were acquired from healthy subjects and five myotonic dystrophy type 1 subjects during resting state and foot movement. Resting state EEG band power, event-related desynchronization/synchronization, functional connectivity, and network features (node strength and betweenness centrality) were estimated. A statistical comparison of these indexes between the two groups was run; a linear correlation between event-related desynchronization and motor performance was obtained. RESULTS: Myotonic dystrophy type 1 subjects showed higher theta power over central motor regions and lower beta power over frontal areas, with a decrease of beta node strength over the dominant hemisphere and an increase of betweenness centrality over the vertex. Foot movement in the most impaired myotonic dystrophy type 1 subjects was inefficient in evoking event-related desynchronization. In less severely impaired participants, dominant foot movement was related to a bilateral sensorimotor event-related desynchronization. CONCLUSIONS: Results provide proof of a central dysfunction of movement. Identification of neurophysiological motor patterns in myotonic dystrophy type 1 could provide a guide for tailored therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 74-81 |
| Number of pages | 8 |
| Journal | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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ASJC Scopus subject areas
- Physiology
- Neurology
- Clinical Neurology
- Physiology (medical)
Cite this
Neurophysiological Evidence of Motor Network Reorganization in Myotonic Dystrophy Type 1 : A Pilot Magnetoencephalographic Study. / Formaggio, Emanuela; Del Felice, Alessandra; Turco, Cristina; Cudia, Paola; Baba, Alfonc; Bevilacqua, Francesca; Masiero, Stefano; Piccione, Francesco.
In: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, Vol. 36, No. 1, 01.01.2019, p. 74-81.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Neurophysiological Evidence of Motor Network Reorganization in Myotonic Dystrophy Type 1
T2 - A Pilot Magnetoencephalographic Study
AU - Formaggio, Emanuela
AU - Del Felice, Alessandra
AU - Turco, Cristina
AU - Cudia, Paola
AU - Baba, Alfonc
AU - Bevilacqua, Francesca
AU - Masiero, Stefano
AU - Piccione, Francesco
PY - 2019/1/1
Y1 - 2019/1/1
N2 - PURPOSE: Myotonic dystrophy type 1 is the most common muscular dystrophy in adults. Although brain involvement is well recognized, the relationship between cortical motor control and voluntary movement has not been sufficiently explored. This study aims at assessing magnetoencephalographic (MEG) rhythms at oscillatory and connectivity levels to map central motor control. METHODS: Magnetoencephalographic data were acquired from healthy subjects and five myotonic dystrophy type 1 subjects during resting state and foot movement. Resting state EEG band power, event-related desynchronization/synchronization, functional connectivity, and network features (node strength and betweenness centrality) were estimated. A statistical comparison of these indexes between the two groups was run; a linear correlation between event-related desynchronization and motor performance was obtained. RESULTS: Myotonic dystrophy type 1 subjects showed higher theta power over central motor regions and lower beta power over frontal areas, with a decrease of beta node strength over the dominant hemisphere and an increase of betweenness centrality over the vertex. Foot movement in the most impaired myotonic dystrophy type 1 subjects was inefficient in evoking event-related desynchronization. In less severely impaired participants, dominant foot movement was related to a bilateral sensorimotor event-related desynchronization. CONCLUSIONS: Results provide proof of a central dysfunction of movement. Identification of neurophysiological motor patterns in myotonic dystrophy type 1 could provide a guide for tailored therapy.
AB - PURPOSE: Myotonic dystrophy type 1 is the most common muscular dystrophy in adults. Although brain involvement is well recognized, the relationship between cortical motor control and voluntary movement has not been sufficiently explored. This study aims at assessing magnetoencephalographic (MEG) rhythms at oscillatory and connectivity levels to map central motor control. METHODS: Magnetoencephalographic data were acquired from healthy subjects and five myotonic dystrophy type 1 subjects during resting state and foot movement. Resting state EEG band power, event-related desynchronization/synchronization, functional connectivity, and network features (node strength and betweenness centrality) were estimated. A statistical comparison of these indexes between the two groups was run; a linear correlation between event-related desynchronization and motor performance was obtained. RESULTS: Myotonic dystrophy type 1 subjects showed higher theta power over central motor regions and lower beta power over frontal areas, with a decrease of beta node strength over the dominant hemisphere and an increase of betweenness centrality over the vertex. Foot movement in the most impaired myotonic dystrophy type 1 subjects was inefficient in evoking event-related desynchronization. In less severely impaired participants, dominant foot movement was related to a bilateral sensorimotor event-related desynchronization. CONCLUSIONS: Results provide proof of a central dysfunction of movement. Identification of neurophysiological motor patterns in myotonic dystrophy type 1 could provide a guide for tailored therapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=85059497077&partnerID=8YFLogxK
U2 - 10.1097/WNP.0000000000000508
DO - 10.1097/WNP.0000000000000508
M3 - Article
C2 - 30247381
AN - SCOPUS:85059497077
VL - 36
SP - 74
EP - 81
JO - Journal of Clinical Neurophysiology
JF - Journal of Clinical Neurophysiology
SN - 0736-0258
IS - 1
ER -