Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome

Michele Tinazzi, Giampietro Zanette, Dino Volpato, Ruggero Testoni, Claudio Bonato, Paolo Manganotti, Carlo Miniussi, Antonio Fiaschi

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The human somatosensory cortex (S1) is capable of modification after partial peripheral deafferentation, but it is not known whether spinal and brainstem changes contribute to this process. We recorded spinal, brainstem and cortical somatosensory evoked potentials following ulnar nerve stimulation in patients affected by unilateral carpal tunnel syndrome with EMG evidence of chronic alterations in median nerve sensorimotor conduction at the wrist lasting at least 4 weeks, and compared them with those from the unaffected hand and with those obtained in a control group. Amplitudes of spinal N13 and brainstem P14 potentials following stimulation of the ulnar nerve ipsilateral to the deafferented median nerve were greater than those following stimulation of the contralateral ulnar nerve. Side-to-side amplitude differences in N13 and P14 were greater in patients than in the control group. Parietal N20 and P27 potentials, supposedly generated in S1, were also significantly increased. The present results suggest that a chronic pathological modification of peripheral sensorimotor inputs is associated with changes in neural activity at multiple sites of the somatosensory system. Changes in spinal and brainstem structures could contribute to the mechanisms subserving changes in the S1. Changes in synaptic strength and unmasking inputs secondary to disconnection of the normally dominant inputs to the 'median nerve' cortex may be the mechanisms underlying ulnar nerve SEP changes.

Original languageEnglish
Pages (from-to)1785-1794
Number of pages10
JournalBrain
Volume121
Issue number9
DOIs
Publication statusPublished - 1998

Fingerprint

Neuronal Plasticity
Ulnar Nerve
Carpal Tunnel Syndrome
Brain Stem
Median Nerve
Control Groups
Somatosensory Cortex
Somatosensory Evoked Potentials
Neural Conduction
Wrist
Hand

Keywords

  • Brain plasticity
  • Carpal tunnel syndrome
  • Deafferentation
  • Sensorimotor cortex
  • Somatosensory evoked potentials

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tinazzi, M., Zanette, G., Volpato, D., Testoni, R., Bonato, C., Manganotti, P., ... Fiaschi, A. (1998). Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome. Brain, 121(9), 1785-1794. https://doi.org/10.1093/brain/121.9.1785

Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome. / Tinazzi, Michele; Zanette, Giampietro; Volpato, Dino; Testoni, Ruggero; Bonato, Claudio; Manganotti, Paolo; Miniussi, Carlo; Fiaschi, Antonio.

In: Brain, Vol. 121, No. 9, 1998, p. 1785-1794.

Research output: Contribution to journalArticle

Tinazzi, M, Zanette, G, Volpato, D, Testoni, R, Bonato, C, Manganotti, P, Miniussi, C & Fiaschi, A 1998, 'Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome', Brain, vol. 121, no. 9, pp. 1785-1794. https://doi.org/10.1093/brain/121.9.1785
Tinazzi, Michele ; Zanette, Giampietro ; Volpato, Dino ; Testoni, Ruggero ; Bonato, Claudio ; Manganotti, Paolo ; Miniussi, Carlo ; Fiaschi, Antonio. / Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome. In: Brain. 1998 ; Vol. 121, No. 9. pp. 1785-1794.
@article{f12241c3982e4eb9a7210764a8b7830d,
title = "Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome",
abstract = "The human somatosensory cortex (S1) is capable of modification after partial peripheral deafferentation, but it is not known whether spinal and brainstem changes contribute to this process. We recorded spinal, brainstem and cortical somatosensory evoked potentials following ulnar nerve stimulation in patients affected by unilateral carpal tunnel syndrome with EMG evidence of chronic alterations in median nerve sensorimotor conduction at the wrist lasting at least 4 weeks, and compared them with those from the unaffected hand and with those obtained in a control group. Amplitudes of spinal N13 and brainstem P14 potentials following stimulation of the ulnar nerve ipsilateral to the deafferented median nerve were greater than those following stimulation of the contralateral ulnar nerve. Side-to-side amplitude differences in N13 and P14 were greater in patients than in the control group. Parietal N20 and P27 potentials, supposedly generated in S1, were also significantly increased. The present results suggest that a chronic pathological modification of peripheral sensorimotor inputs is associated with changes in neural activity at multiple sites of the somatosensory system. Changes in spinal and brainstem structures could contribute to the mechanisms subserving changes in the S1. Changes in synaptic strength and unmasking inputs secondary to disconnection of the normally dominant inputs to the 'median nerve' cortex may be the mechanisms underlying ulnar nerve SEP changes.",
keywords = "Brain plasticity, Carpal tunnel syndrome, Deafferentation, Sensorimotor cortex, Somatosensory evoked potentials",
author = "Michele Tinazzi and Giampietro Zanette and Dino Volpato and Ruggero Testoni and Claudio Bonato and Paolo Manganotti and Carlo Miniussi and Antonio Fiaschi",
year = "1998",
doi = "10.1093/brain/121.9.1785",
language = "English",
volume = "121",
pages = "1785--1794",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome

AU - Tinazzi, Michele

AU - Zanette, Giampietro

AU - Volpato, Dino

AU - Testoni, Ruggero

AU - Bonato, Claudio

AU - Manganotti, Paolo

AU - Miniussi, Carlo

AU - Fiaschi, Antonio

PY - 1998

Y1 - 1998

N2 - The human somatosensory cortex (S1) is capable of modification after partial peripheral deafferentation, but it is not known whether spinal and brainstem changes contribute to this process. We recorded spinal, brainstem and cortical somatosensory evoked potentials following ulnar nerve stimulation in patients affected by unilateral carpal tunnel syndrome with EMG evidence of chronic alterations in median nerve sensorimotor conduction at the wrist lasting at least 4 weeks, and compared them with those from the unaffected hand and with those obtained in a control group. Amplitudes of spinal N13 and brainstem P14 potentials following stimulation of the ulnar nerve ipsilateral to the deafferented median nerve were greater than those following stimulation of the contralateral ulnar nerve. Side-to-side amplitude differences in N13 and P14 were greater in patients than in the control group. Parietal N20 and P27 potentials, supposedly generated in S1, were also significantly increased. The present results suggest that a chronic pathological modification of peripheral sensorimotor inputs is associated with changes in neural activity at multiple sites of the somatosensory system. Changes in spinal and brainstem structures could contribute to the mechanisms subserving changes in the S1. Changes in synaptic strength and unmasking inputs secondary to disconnection of the normally dominant inputs to the 'median nerve' cortex may be the mechanisms underlying ulnar nerve SEP changes.

AB - The human somatosensory cortex (S1) is capable of modification after partial peripheral deafferentation, but it is not known whether spinal and brainstem changes contribute to this process. We recorded spinal, brainstem and cortical somatosensory evoked potentials following ulnar nerve stimulation in patients affected by unilateral carpal tunnel syndrome with EMG evidence of chronic alterations in median nerve sensorimotor conduction at the wrist lasting at least 4 weeks, and compared them with those from the unaffected hand and with those obtained in a control group. Amplitudes of spinal N13 and brainstem P14 potentials following stimulation of the ulnar nerve ipsilateral to the deafferented median nerve were greater than those following stimulation of the contralateral ulnar nerve. Side-to-side amplitude differences in N13 and P14 were greater in patients than in the control group. Parietal N20 and P27 potentials, supposedly generated in S1, were also significantly increased. The present results suggest that a chronic pathological modification of peripheral sensorimotor inputs is associated with changes in neural activity at multiple sites of the somatosensory system. Changes in spinal and brainstem structures could contribute to the mechanisms subserving changes in the S1. Changes in synaptic strength and unmasking inputs secondary to disconnection of the normally dominant inputs to the 'median nerve' cortex may be the mechanisms underlying ulnar nerve SEP changes.

KW - Brain plasticity

KW - Carpal tunnel syndrome

KW - Deafferentation

KW - Sensorimotor cortex

KW - Somatosensory evoked potentials

UR - http://www.scopus.com/inward/record.url?scp=0031710014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031710014&partnerID=8YFLogxK

U2 - 10.1093/brain/121.9.1785

DO - 10.1093/brain/121.9.1785

M3 - Article

VL - 121

SP - 1785

EP - 1794

JO - Brain

JF - Brain

SN - 0006-8950

IS - 9

ER -