Neurophysiological examination of end-plate function in patients with lung cancer

B. Jandolo, M. D. Giulia, A. Pace, A. Pietrangeli, L. Bove, P. Innocenti, M. Lopez

Research output: Contribution to journalArticlepeer-review


Twenty-eight patients affected by lung cancer were studied with neurophysiological and clinical examinations to show the prevalence of alteration of neuromuscular transmission. During repetitive stimulation at 20 Hz we found in 6 cases (22%) an increment (> 20%) and in 4 cases a decrement (> 10%) of the size of muscle action potentials. In 15 patients (57%) we found low sensory action potential amplitude (<11 μv). In 3 (11%) of the 6 cases with incremental response the overall examination suggested a disorder of neuromuscular junction such as Eaton-Lambert syndrome. Our results suggest that the peripheral nervous system involvement in patients affected by lung cancer is higher than usually estimated.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalElectromyography and Clinical Neurophysiology
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology

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