Neurophysiology of synaptic functioning in multiple sclerosis

Mario Stampanoni Bassi, Francesco Mori, Fabio Buttari, Girolama A. Marfia, Andrea Sancesario, Diego Centonze, Ennio Iezzi

Research output: Contribution to journalReview article

Abstract

Multiple sclerosis (MS) is an inflammatory immune-mediate disorder of the central nervous system (CNS), primarily affecting the myelin sheath and followed by neurodegeneration. Synaptic alterations are emerging as critical determinants of early neurodegeneration in MS. Inflammation-induced alterations of synaptic transmission and plasticity have been investigated in vitro and also in human MS using transcranial magnetic stimulation (TMS) techniques. Specific inflammatory cytokines alter glutamatergic and GABAergic transmission, resulting in synaptic hyperexcitability. In both experimental autoimmune encephalomyelitis (EAE) and MS, excitotoxic damage and neurodegeneration are found even in the early phases of disease, conversely inflammation persists in the progressive phases. Inflammatory cytokines also affect synaptic plasticity, as both long-term potentiation (LTP) and long-term depression (LTD) are altered in EAE and in MS patients. In particular, inflammation profoundly subverts plasticity and influence both clinical recovery after a relapse and disease course. Regulation of neuronal activity by cytokines plays important roles in the neuro-immune crosstalk involved in inflammation-associated excitotoxic neuronal damage, and in the chance of developing compensatory plasticity. Innate and adaptive immunity interact with the CNS in MS, in line with the concept that cytokines and chemokines, in concert with neurotransmitters and neuropeptides, represent a major communication system in the CNS.

Original languageEnglish
Pages (from-to)1148-1157
Number of pages10
JournalClinical Neurophysiology
Volume128
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Neurophysiology
Multiple Sclerosis
Cytokines
Inflammation
Neuronal Plasticity
Autoimmune Experimental Encephalomyelitis
Central Nervous System
Transcranial Magnetic Stimulation
Long-Term Potentiation
Immune System Diseases
Adaptive Immunity
Myelin Sheath
Neuropeptides
Chemokines
Innate Immunity
Synaptic Transmission
Neurotransmitter Agents
Communication
Depression
Recurrence

Keywords

  • Experimental autoimmune encephalomyelitis
  • Inflammatory cytokines
  • Multiple sclerosis
  • Neurodegeneration
  • Synaptic plasticity
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Neurophysiology of synaptic functioning in multiple sclerosis. / Stampanoni Bassi, Mario; Mori, Francesco; Buttari, Fabio; Marfia, Girolama A.; Sancesario, Andrea; Centonze, Diego; Iezzi, Ennio.

In: Clinical Neurophysiology, Vol. 128, No. 7, 01.07.2017, p. 1148-1157.

Research output: Contribution to journalReview article

Stampanoni Bassi, Mario ; Mori, Francesco ; Buttari, Fabio ; Marfia, Girolama A. ; Sancesario, Andrea ; Centonze, Diego ; Iezzi, Ennio. / Neurophysiology of synaptic functioning in multiple sclerosis. In: Clinical Neurophysiology. 2017 ; Vol. 128, No. 7. pp. 1148-1157.
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