Neuroprotection: The emerging concept of restorative neural stem cell biology for the treatment of neurodegenerative diseases

Barbara Carletti, Fiorella Piemonte, Ferdinando Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare parts for cell replacement therapies, NSCs could play a key role in the pharmacology of neuroprotection and become protagonists of innovative treatments for neurodegenerative diseases. Here, we review this new emerging concept of NSC biology.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalCurrent Neuropharmacology
Volume9
Issue number2
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Neural stem cells
  • Neurodegenerative disorders
  • Neuroprotection
  • Neurotrophic factors
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

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