Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum

R. Fancellu, M. T. Armentero, G. Nappi, F. Blandini

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In rats, intrastriatal injection of malonate, a reversible inhibitor of the mitochondrial enzyme succinate dehydrogenase, induces a lesion similar to that observed following focal ischemia or in Huntington's disease. In this study we used the malonate model to explore the neuroprotective potential of dopamine agonists. Rats were injected intraperitoneally with increasing concentrations of D1, D2, or mixed D1/D2 dopamine agonists prior to intrastriatal injection of malonate. Administration of increasing doses of the D2-specific agonist quinpirole resulted in increased protection against malonate toxicity. Conversely, the D1-specific agonist SKF-38393, as well as the mixed D1/D2 agonist apomorphine, conferred higher neuroprotection at lower than at higher drug concentrations. Our data suggest that malonate-induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D1 and D2 agonists showing different profiles of efficacy.

Original languageEnglish
Pages (from-to)180-181
Number of pages2
JournalNeurological Sciences
Volume24
Issue number3
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Dopamine Agonists
Neuroprotective Agents
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Corpus Striatum
Injections
Succinate Dehydrogenase
Apomorphine
Huntington Disease
Enzyme Inhibitors
Ischemia
malonic acid
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum. / Fancellu, R.; Armentero, M. T.; Nappi, G.; Blandini, F.

In: Neurological Sciences, Vol. 24, No. 3, 10.2003, p. 180-181.

Research output: Contribution to journalArticle

@article{d4b44b54754e4229b9ac14f13670678d,
title = "Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum",
abstract = "In rats, intrastriatal injection of malonate, a reversible inhibitor of the mitochondrial enzyme succinate dehydrogenase, induces a lesion similar to that observed following focal ischemia or in Huntington's disease. In this study we used the malonate model to explore the neuroprotective potential of dopamine agonists. Rats were injected intraperitoneally with increasing concentrations of D1, D2, or mixed D1/D2 dopamine agonists prior to intrastriatal injection of malonate. Administration of increasing doses of the D2-specific agonist quinpirole resulted in increased protection against malonate toxicity. Conversely, the D1-specific agonist SKF-38393, as well as the mixed D1/D2 agonist apomorphine, conferred higher neuroprotection at lower than at higher drug concentrations. Our data suggest that malonate-induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D1 and D2 agonists showing different profiles of efficacy.",
author = "R. Fancellu and Armentero, {M. T.} and G. Nappi and F. Blandini",
year = "2003",
month = "10",
doi = "10.1007/s10072-003-0119-x",
language = "English",
volume = "24",
pages = "180--181",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "3",

}

TY - JOUR

T1 - Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum

AU - Fancellu, R.

AU - Armentero, M. T.

AU - Nappi, G.

AU - Blandini, F.

PY - 2003/10

Y1 - 2003/10

N2 - In rats, intrastriatal injection of malonate, a reversible inhibitor of the mitochondrial enzyme succinate dehydrogenase, induces a lesion similar to that observed following focal ischemia or in Huntington's disease. In this study we used the malonate model to explore the neuroprotective potential of dopamine agonists. Rats were injected intraperitoneally with increasing concentrations of D1, D2, or mixed D1/D2 dopamine agonists prior to intrastriatal injection of malonate. Administration of increasing doses of the D2-specific agonist quinpirole resulted in increased protection against malonate toxicity. Conversely, the D1-specific agonist SKF-38393, as well as the mixed D1/D2 agonist apomorphine, conferred higher neuroprotection at lower than at higher drug concentrations. Our data suggest that malonate-induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D1 and D2 agonists showing different profiles of efficacy.

AB - In rats, intrastriatal injection of malonate, a reversible inhibitor of the mitochondrial enzyme succinate dehydrogenase, induces a lesion similar to that observed following focal ischemia or in Huntington's disease. In this study we used the malonate model to explore the neuroprotective potential of dopamine agonists. Rats were injected intraperitoneally with increasing concentrations of D1, D2, or mixed D1/D2 dopamine agonists prior to intrastriatal injection of malonate. Administration of increasing doses of the D2-specific agonist quinpirole resulted in increased protection against malonate toxicity. Conversely, the D1-specific agonist SKF-38393, as well as the mixed D1/D2 agonist apomorphine, conferred higher neuroprotection at lower than at higher drug concentrations. Our data suggest that malonate-induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D1 and D2 agonists showing different profiles of efficacy.

UR - http://www.scopus.com/inward/record.url?scp=0142217552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142217552&partnerID=8YFLogxK

U2 - 10.1007/s10072-003-0119-x

DO - 10.1007/s10072-003-0119-x

M3 - Article

VL - 24

SP - 180

EP - 181

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 3

ER -