Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals

Marco Fiocchetti, Paolo Ascenzi, Maria Marino

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Besides its crucial role in many physiological events, 17β-estradiol (E2) exerts protective effects in the central nervous system. The E2 effects are not restricted to the brain areas related with the control of reproductive function, but rather are widespread throughout the developing and the adult brain. E2 actions are mediated through estrogen receptors (i.e., ERα and ERβ) belonging to the nuclear receptor super-family. As members of the ligand-regulated transcription factor family, classically, the actions of ERs in the brain were thought to mediate only the E2 long-term transcriptional effects. However, a growing body of evidence highlighted rapid, membrane initiated E2 effects in the brain that are independent of ER transcriptional activities and are involved in E2-induced neuroprotection. The aim of this review is to focus on the rapid effects of E2 in the brain highlighting the specific role of the signaling pathway(s) of the ERβ subtype in the neuroprotective actions of E2.

Original languageEnglish
Article numberArticle 73
JournalFrontiers in Physiology
Volume3 APR
DOIs
Publication statusPublished - 2012

Fingerprint

Neuroprotective Agents
Estrogen Receptors
Estradiol
Membranes
Brain
Cytoplasmic and Nuclear Receptors
Transcription Factors
Central Nervous System
Ligands

Keywords

  • 17β-estradiol
  • Estrogen receptor α
  • Estrogen receptor β
  • Membrane initiated signals
  • Neuroprotective effects

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals. / Fiocchetti, Marco; Ascenzi, Paolo; Marino, Maria.

In: Frontiers in Physiology, Vol. 3 APR, Article 73, 2012.

Research output: Contribution to journalArticle

Fiocchetti, Marco ; Ascenzi, Paolo ; Marino, Maria. / Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals. In: Frontiers in Physiology. 2012 ; Vol. 3 APR.
@article{ebb4002bf5c4490ebc8a7c17f4ecbbe7,
title = "Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals",
abstract = "Besides its crucial role in many physiological events, 17β-estradiol (E2) exerts protective effects in the central nervous system. The E2 effects are not restricted to the brain areas related with the control of reproductive function, but rather are widespread throughout the developing and the adult brain. E2 actions are mediated through estrogen receptors (i.e., ERα and ERβ) belonging to the nuclear receptor super-family. As members of the ligand-regulated transcription factor family, classically, the actions of ERs in the brain were thought to mediate only the E2 long-term transcriptional effects. However, a growing body of evidence highlighted rapid, membrane initiated E2 effects in the brain that are independent of ER transcriptional activities and are involved in E2-induced neuroprotection. The aim of this review is to focus on the rapid effects of E2 in the brain highlighting the specific role of the signaling pathway(s) of the ERβ subtype in the neuroprotective actions of E2.",
keywords = "17β-estradiol, Estrogen receptor α, Estrogen receptor β, Membrane initiated signals, Neuroprotective effects",
author = "Marco Fiocchetti and Paolo Ascenzi and Maria Marino",
year = "2012",
doi = "10.3389/fphys.2012.00073",
language = "English",
volume = "3 APR",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals

AU - Fiocchetti, Marco

AU - Ascenzi, Paolo

AU - Marino, Maria

PY - 2012

Y1 - 2012

N2 - Besides its crucial role in many physiological events, 17β-estradiol (E2) exerts protective effects in the central nervous system. The E2 effects are not restricted to the brain areas related with the control of reproductive function, but rather are widespread throughout the developing and the adult brain. E2 actions are mediated through estrogen receptors (i.e., ERα and ERβ) belonging to the nuclear receptor super-family. As members of the ligand-regulated transcription factor family, classically, the actions of ERs in the brain were thought to mediate only the E2 long-term transcriptional effects. However, a growing body of evidence highlighted rapid, membrane initiated E2 effects in the brain that are independent of ER transcriptional activities and are involved in E2-induced neuroprotection. The aim of this review is to focus on the rapid effects of E2 in the brain highlighting the specific role of the signaling pathway(s) of the ERβ subtype in the neuroprotective actions of E2.

AB - Besides its crucial role in many physiological events, 17β-estradiol (E2) exerts protective effects in the central nervous system. The E2 effects are not restricted to the brain areas related with the control of reproductive function, but rather are widespread throughout the developing and the adult brain. E2 actions are mediated through estrogen receptors (i.e., ERα and ERβ) belonging to the nuclear receptor super-family. As members of the ligand-regulated transcription factor family, classically, the actions of ERs in the brain were thought to mediate only the E2 long-term transcriptional effects. However, a growing body of evidence highlighted rapid, membrane initiated E2 effects in the brain that are independent of ER transcriptional activities and are involved in E2-induced neuroprotection. The aim of this review is to focus on the rapid effects of E2 in the brain highlighting the specific role of the signaling pathway(s) of the ERβ subtype in the neuroprotective actions of E2.

KW - 17β-estradiol

KW - Estrogen receptor α

KW - Estrogen receptor β

KW - Membrane initiated signals

KW - Neuroprotective effects

UR - http://www.scopus.com/inward/record.url?scp=84866330312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866330312&partnerID=8YFLogxK

U2 - 10.3389/fphys.2012.00073

DO - 10.3389/fphys.2012.00073

M3 - Article

VL - 3 APR

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - Article 73

ER -