Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy

Lucia Buccarello, Giuliano Grignaschi, Alessia Di Giancamillo, Cinzia Domeneghini, Roberto Cosimo Melcangi, Tiziana Borsello

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Abstract

Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain. Although numerous studies in mouse models of Alzheimer disease (AD) have shown a correlation among diet, beta-amyloid and AD onset, little is known about the impact of diet on Tau. We investigated whether a low fat-protein diet (LFPD) may improve lifespan, cognitive and locomotor activity in P301L-tg mouse model of tauopathy. Our data indicate that LFPD has a beneficial effect on these parameters. Tg mice fed with standard diet shown a decrease in body weight, food intake and survival rate if compared to wild type animals. In contrast, LFPD counteracted weight loss, increased mortality and ameliorated cognitive and locomotor performances in tg mice. LFPD also reduced the abnormal accumulation of agglomerates of P-Tau (pathological features of tauopathies) and the expression of apoptotic markers (i.e., TUNEL immunopositive neurons) in the prefrontal cerebral cortex and hippocampus of P301L-tg mice. Interestingly, some of these effects are sex-dependent. For instance, tg females, but not males, fed with LFPD had a significant increase of body weight and a reduction of P-Tau agglomerates compared to tg fed with standard diet. These changes correlated with a more pronounced improvement of cognition and locomotor activity in females than in male tg fed with LFPD. Altogether, these results suggest a sex dependent neuroprotective effect of LFPD in P301L-tg mice, suggesting that lifestyle intervention strategies may be clinically relevant for delaying the onset of cognitive impairment and dementia, especially in females.

Original languageEnglish
Pages (from-to)208-220
Number of pages13
JournalNeuroscience
Volume354
DOIs
Publication statusPublished - Jun 23 2017

Fingerprint

Tauopathies
Protein-Restricted Diet
Fat-Restricted Diet
Neuroprotective Agents
Diet
Locomotion
Weight Loss
Alzheimer Disease
Body Weight
Wild Animals
In Situ Nick-End Labeling
Prefrontal Cortex
Amyloid
Neurodegenerative Diseases
Cerebral Cortex
Cognition
Dementia
Life Style
Hippocampus
Survival Rate

Keywords

  • diet
  • hyperphosphorylated Tau
  • neuronal death
  • neuroprotection
  • sex difference
  • tauopathy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Buccarello, L., Grignaschi, G., Di Giancamillo, A., Domeneghini, C., Melcangi, R. C., & Borsello, T. (2017). Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy. Neuroscience, 354, 208-220. https://doi.org/10.1016/j.neuroscience.2017.04.027

Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy. / Buccarello, Lucia; Grignaschi, Giuliano; Di Giancamillo, Alessia; Domeneghini, Cinzia; Melcangi, Roberto Cosimo; Borsello, Tiziana.

In: Neuroscience, Vol. 354, 23.06.2017, p. 208-220.

Research output: Contribution to journalArticle

Buccarello, L, Grignaschi, G, Di Giancamillo, A, Domeneghini, C, Melcangi, RC & Borsello, T 2017, 'Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy', Neuroscience, vol. 354, pp. 208-220. https://doi.org/10.1016/j.neuroscience.2017.04.027
Buccarello, Lucia ; Grignaschi, Giuliano ; Di Giancamillo, Alessia ; Domeneghini, Cinzia ; Melcangi, Roberto Cosimo ; Borsello, Tiziana. / Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy. In: Neuroscience. 2017 ; Vol. 354. pp. 208-220.
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