TY - GEN
T1 - Neuroprotective effects of thymosin β4 in experimental models of excitotoxicity
AU - Popoli, Patrizia
AU - Pepponi, Rita
AU - Martire, Alberto
AU - Armida, Monica
AU - Pèzzola, Antonella
AU - Galluzzo, Mariangela
AU - Domenici, M. Rosaria
AU - Potenza, Rosa Luisa
AU - Tebano, M. Teresa
AU - Mollinari, Cristiana
AU - Merlo, Daniela
AU - Garaci, Enrico
PY - 2007/9
Y1 - 2007/9
N2 - The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β4, are worthy of further investigations.
AB - The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β4, are worthy of further investigations.
KW - Excitotoxicity
KW - Thymosin β
UR - http://www.scopus.com/inward/record.url?scp=35348933671&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35348933671&partnerID=8YFLogxK
U2 - 10.1196/annals.1415.033
DO - 10.1196/annals.1415.033
M3 - Conference contribution
C2 - 17947590
AN - SCOPUS:35348933671
SN - 1573317012
SN - 9781573317016
VL - 1112
T3 - Annals of the New York Academy of Sciences
SP - 219
EP - 224
BT - Annals of the New York Academy of Sciences
ER -