Neuroprotective effects of thymosin β4 in experimental models of excitotoxicity

Patrizia Popoli, Rita Pepponi, Alberto Martire, Monica Armida, Antonella Pèzzola, Mariangela Galluzzo, M. Rosaria Domenici, Rosa Luisa Potenza, M. Teresa Tebano, Cristiana Mollinari, Daniela Merlo, Enrico Garaci

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β4, are worthy of further investigations.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages219-224
Number of pages6
Volume1112
DOIs
Publication statusPublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1112
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Excitotoxicity
  • Thymosin β

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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