Neuroprotective effects of thymosin β4 in experimental models of excitotoxicity

Patrizia Popoli; Rita Pepponi; Alberto Martire; Monica Armida; Antonella Pèzzola; Mariangela Galluzzo; M. Rosaria Domenici; Rosa Luisa Potenza; M. Teresa Tebano; Cristiana Mollinari; Daniela Merlo; Enrico Garaci

doi:10.1196/annals.1415.033

Neuroprotective effects of thymosin β4 in experimental models of excitotoxicity

Patrizia Popoli, Rita Pepponi, Alberto Martire, Monica Armida, Antonella Pèzzola, Mariangela Galluzzo, M. Rosaria Domenici, Rosa Luisa Potenza, M. Teresa Tebano, Cristiana Mollinari, Daniela Merlo, Enrico Garaci

Istituto San Raffaele Pisana

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The aim of this study was to evaluate the possible neuroprotective effects of thymosin β₄ in different models of excitotoxicity. The application of thymosin β₄ significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β₄ significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β₄ induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β₄, are worthy of further investigations.

Original language	English
Title of host publication	Annals of the New York Academy of Sciences
Pages	219-224
Number of pages	6
Volume	1112
DOIs	https://doi.org/10.1196/annals.1415.033
Publication status	Published - Sep 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1112
ISSN (Print)	00778923
ISSN (Electronic)	17496632

Keywords

Excitotoxicity
Thymosin β

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1196/annals.1415.033

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Popoli, P., Pepponi, R., Martire, A., Armida, M., Pèzzola, A., Galluzzo, M., Domenici, M. R., Potenza, R. L., Tebano, M. T., Mollinari, C., Merlo, D., & Garaci, E. (2007). Neuroprotective effects of thymosin β4 in experimental models of excitotoxicity. In Annals of the New York Academy of Sciences (Vol. 1112, pp. 219-224). (Annals of the New York Academy of Sciences; Vol. 1112). https://doi.org/10.1196/annals.1415.033

Popoli, P, Pepponi, R, Martire, A, Armida, M, Pèzzola, A, Galluzzo, M, Domenici, MR, Potenza, RL, Tebano, MT, Mollinari, C, Merlo, D & Garaci, E 2007, Neuroprotective effects of thymosin β4 in experimental models of excitotoxicity. in Annals of the New York Academy of Sciences. vol. 1112, Annals of the New York Academy of Sciences, vol. 1112, pp. 219-224. https://doi.org/10.1196/annals.1415.033

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abstract = "The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β4, are worthy of further investigations.",

keywords = "Excitotoxicity, Thymosin β",

author = "Patrizia Popoli and Rita Pepponi and Alberto Martire and Monica Armida and Antonella P{\`e}zzola and Mariangela Galluzzo and Domenici, {M. Rosaria} and Potenza, {Rosa Luisa} and Tebano, {M. Teresa} and Cristiana Mollinari and Daniela Merlo and Enrico Garaci",

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month = sep,

doi = "10.1196/annals.1415.033",

language = "English",

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AU - Popoli, Patrizia

AU - Pepponi, Rita

AU - Martire, Alberto

AU - Armida, Monica

AU - Pèzzola, Antonella

AU - Galluzzo, Mariangela

AU - Domenici, M. Rosaria

AU - Potenza, Rosa Luisa

AU - Tebano, M. Teresa

AU - Mollinari, Cristiana

AU - Merlo, Daniela

AU - Garaci, Enrico

PY - 2007/9

Y1 - 2007/9

N2 - The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β4, are worthy of further investigations.

AB - The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β4, are worthy of further investigations.

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KW - Thymosin β

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T3 - Annals of the New York Academy of Sciences

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Neuroprotective effects of thymosin β4 in experimental models of excitotoxicity

Abstract

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