Neuroprotective potential of secondary metabolites from melicope lunu-ankenda (Rutaceae)

Zeinab Abdulwanis Mohamed, Enas Mohamed Eliaser, Emanuela Mazzon, Patrick Rollin, Gwendoline Cheng Lian Ee, Ahmad Faizal Abdull Razis

Research output: Contribution to journalReview articlepeer-review


Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. Melicope lunu-ankenda is one Melicope species (family Rutaceae), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the M. lunu-ankenda plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of M. lunu-ankenda major secondary metabolites in neurodegenerative diseases.

Original languageEnglish
Article number3109
Issue number17
Publication statusPublished - Aug 27 2019


  • Alkaloids
  • Coumarins
  • Melicope lunu-ankenda
  • Neurodegenerative diseases
  • Neuroprotection
  • Polyphenols

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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